論文 - 詳細
| RRC ID | 72837 |
|---|---|
| 著者 | Nagai K, Tahara-Hanaoka S, Morishima Y, Tokunaga T, Imoto Y, Noguchi E, Kanemaru K, Imai M, Shibayama S, Hizawa N, Fujieda S, Yamagata K, Shibuya A. |
| タイトル | Expression and function of Allergin-1 on human primary mast cells. |
| ジャーナル | PLoS One |
| Abstract |
Mast cells (MC) play an important role in allergic and non-allergic immune responses. Activation of human MC is modulated by several cell surface inhibitory receptors, including recently identified Allergin-1 expressed on both human and mouse MC. Although Allergin-1 suppresses IgE-mediated, mast cell-dependent anaphylaxis in mice, the expression profile and function of Allergin-1 on human primary MC remains undetermined. Here, we established a seven-color flow cytometry method for assessing expression and function of a very small number of human primary MC. We show that Allergin-1S1, a splicing isoform of Allergin-1, is predominantly expressed on human primary MC in both bronchoalveolar lavage (BAL) fluid and nasal scratching specimens. Moreover, Allergin-1S1 inhibits IgE-mediated activation from human primary MC in BAL fluid. These results indicate that Allergin-1 on human primary MC exhibits similar characteristics as mouse Allergin-1 in the expression profile and function. |
| 巻・号 | 8(10) |
| ページ | e76160 |
| 公開日 | 2013-1-1 |
| DOI | 10.1371/journal.pone.0076160 |
| PII | PONE-D-13-27350 |
| PMID | 24116093 |
| PMC | PMC3792105 |
| MeSH | Bronchoalveolar Lavage Fluid / cytology Flow Cytometry Humans Immunoglobulin E / immunology Immunoglobulin E / metabolism Mast Cells / cytology Mast Cells / immunology Mast Cells / metabolism* Receptors, Immunologic / genetics Receptors, Immunologic / metabolism* |
| IF | 2.74 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 研究用ヒト臍帯血幹細胞 | |