論文 - 詳細
| RRC ID | 72912 |
|---|---|
| 著者 | Sueoka E, Sueoka N, Kai Y, Okabe S, Suganuma M, Kanematsu K, Yamamoto T, Fujiki H. |
| タイトル | Anticancer activity of morphine and its synthetic derivative, KT-90, mediated through apoptosis and inhibition of NF-kappaB activation. |
| ジャーナル | Biochem Biophys Res Commun |
| Abstract |
We recently reported that morphine inhibits growth of various human cancer cell lines (IC50/2.7-8.8 mM). We then extended the study using newly synthesized morphine derivatives, such as KT-90 and KT-87, which are analgesics 5 times more potent than morphine. KT-90 was found to inhibit growth of human cancer cell lines (IC50/42-70 microM) up to 80 times more potently than morphine. As for mechanisms of action, KT-90 and morphine induced apoptosis, and inhibited tumor necrosis factor alpha (TNF-alpha) gene expression induced by tumor promoters, okadaic acid and 12-O-tetradecanoylphorbol-13-acetate, associated with reduction of NF-kappaB DNA binding activity. This paper provides evidence that KT compounds confirmed the presence of anticancer activity of morphine in addition to its analgesic action. |
| 巻・号 | 252(3) |
| ページ | 566-70 |
| 公開日 | 1998-11-27 |
| DOI | 10.1006/bbrc.1998.9695 |
| PII | S0006-291X(98)99695-4 |
| PMID | 9837747 |
| MeSH | Analgesics / pharmacology* Antineoplastic Agents / pharmacology* Apoptosis* / drug effects Cell Division / drug effects Electrophoresis, Polyacrylamide Gel Gene Expression Regulation, Neoplastic / drug effects Humans Morphine / pharmacology* Morphine Derivatives / pharmacology* NF-kappa B / antagonists & inhibitors* Palliative Care Tumor Cells, Cultured Tumor Necrosis Factor-alpha / metabolism |
| IF | 2.985 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | HL60(RCB0041) U251(RCB0461) |