| RRC ID |
72912
|
| 著者 |
Sueoka E, Sueoka N, Kai Y, Okabe S, Suganuma M, Kanematsu K, Yamamoto T, Fujiki H.
|
| タイトル |
Anticancer activity of morphine and its synthetic derivative, KT-90, mediated through apoptosis and inhibition of NF-kappaB activation.
|
| ジャーナル |
Biochem Biophys Res Commun
|
| Abstract |
We recently reported that morphine inhibits growth of various human cancer cell lines (IC50/2.7-8.8 mM). We then extended the study using newly synthesized morphine derivatives, such as KT-90 and KT-87, which are analgesics 5 times more potent than morphine. KT-90 was found to inhibit growth of human cancer cell lines (IC50/42-70 microM) up to 80 times more potently than morphine. As for mechanisms of action, KT-90 and morphine induced apoptosis, and inhibited tumor necrosis factor alpha (TNF-alpha) gene expression induced by tumor promoters, okadaic acid and 12-O-tetradecanoylphorbol-13-acetate, associated with reduction of NF-kappaB DNA binding activity. This paper provides evidence that KT compounds confirmed the presence of anticancer activity of morphine in addition to its analgesic action.
|
| 巻・号 |
252(3)
|
| ページ |
566-70
|
| 公開日 |
1998-11-27
|
| DOI |
10.1006/bbrc.1998.9695
|
| PII |
S0006-291X(98)99695-4
|
| PMID |
9837747
|
| MeSH |
Analgesics / pharmacology*
Antineoplastic Agents / pharmacology*
Apoptosis* / drug effects
Cell Division / drug effects
Electrophoresis, Polyacrylamide Gel
Gene Expression Regulation, Neoplastic / drug effects
Humans
Morphine / pharmacology*
Morphine Derivatives / pharmacology*
NF-kappa B / antagonists & inhibitors*
Palliative Care
Tumor Cells, Cultured
Tumor Necrosis Factor-alpha / metabolism
|
| IF |
2.985
|
| リソース情報 |
| ヒト・動物細胞 |
HL60(RCB0041)
U251(RCB0461) |
