Reference - Detail
| RRC ID | 72927 |
|---|---|
| Author | Tanaka T, Mizuno K, Umesaki N, Ogita S. |
| Title | Suppressed apoptotic susceptibility in human endometrial epithelial cells pretreated with hepatocyte growth factor. |
| Journal | Clin Exp Obstet Gynecol |
| Abstract |
Hepatocyte growth factor (HGF) and its receptor are strongly expressed perimenstrually in human endometrial epithelium, but their functions remain unknown. In this study the effects of HGF on Fas-mediated apoptosis in the human endometrial epithelial cell line HHUA were investigated. It was found that HGF inhibited Fas-mediated growth suppression and DNA fragmentation in the cells without any increase in Fas antigen expression on the cells. This results suggests that HGF inhibits Fas-mediated apoptotic signals in the endometrium, and possibly plays a role in reshaping the endometrium during menstruation. |
| Volume | 25(4) |
| Pages | 125-8 |
| Published | 1998-1-1 |
| PMID | 9987568 |
| MeSH | Adenocarcinoma / pathology* Apoptosis* Cell Division / drug effects DNA Fragmentation Dose-Response Relationship, Drug Endometrial Neoplasms / pathology* Endometrium / cytology* Endometrium / drug effects Epithelium / pathology Female Flow Cytometry Hepatocyte Growth Factor / metabolism* Hepatocyte Growth Factor / pharmacology Humans Menstruation / metabolism Proto-Oncogene Proteins c-met / metabolism* Tumor Cells, Cultured / pathology fas Receptor / metabolism |
| Resource | |
| Human and Animal Cells | HHUA(RCB0658) |