論文 - 詳細
| RRC ID | 72931 |
|---|---|
| 著者 | Maeda T, Manabe Y, Yamamoto M, Yoshida M, Okazaki K, Nagamune H, Kourai H. |
| タイトル | Synthesis and antimicrobial characteristics of novel biocides, 4,4'-(1,6-hexamethylenedioxydicarbonyl)bis(1-alkylpyridinium++ + iodide)s. |
| ジャーナル | Chem Pharm Bull (Tokyo) |
| Abstract |
Potent new biocides against both bacteria and fungi, 4,4'-(1,6-hexamethylenedioxydicarbonyl)bis(1-alkylpyridinium iodide)s (4DOCBP-6,n) (alkyl chain length, n = 8, 10, 12, 14, 16 and 18) were synthesized, 4DOCBP-6,n is a bis-quaternary ammonium compound (bis-QAC) and has a symmetrical dimeric structure which is composed of two alkylpyridinium iodides connected with a hexamethylenedioxydicarbonyl chain. 4DOCBP-6,10 and 4DOCBP-6,12 exhibited wide and effective antimicrobial spectra, compared with those of typical bactericides, N-dodecylpyridinium iodides (P-12) and benzyldimethyldodecylammonium chloride (BAC), or a popularly-used fungicide, 2-(4-thiazolyl)benzimidazole (TBZ). Their superior properties would be due to the unique dimeric structure which contains two active moieties in a molecule. |
| 巻・号 | 47(7) |
| ページ | 1020-3 |
| 公開日 | 1999-7-1 |
| DOI | 10.1248/cpb.47.1020 |
| PMID | 10434404 |
| MeSH | Anti-Bacterial Agents Anti-Infective Agents / chemical synthesis* Anti-Infective Agents / pharmacology Antifungal Agents / chemical synthesis* Antifungal Agents / pharmacology Bacteria / drug effects Chemical Phenomena Chemistry, Physical Fibroblasts Fungi / drug effects Gram-Negative Bacteria / drug effects Gram-Positive Bacteria / drug effects Iodides / chemical synthesis* Iodides / pharmacology Microbial Sensitivity Tests Pyridines / chemical synthesis* Pyridines / pharmacology Structure-Activity Relationship |
| IF | 1.416 |
| リソース情報 | |
| ヒト・動物細胞 | NB1RGB(RCB0222) |