論文 - 詳細
| RRC ID | 72954 |
|---|---|
| 著者 | Kikuchi T, Okada R, Harada Y, Ikushima K, Yamakawa T, Yamada T, Tanaka R. |
| タイトル | Cucurbitane-type triterpenes from Citrullus lanatus (watermelon) seeds. |
| ジャーナル | Nat Prod Commun |
| Abstract |
Two new cucurbitane-type triterpenes, 24-hydroperoxycucurbita-5,25-dien-3beta-ol (1) and 25-hydroperoxycucurbita-5,23-dien-3beta-ol (2), were isolated from a MeOH extract of Citrullus lanatus seeds. Compounds 1 and 2 exhibited moderate cytotoxic activities with IC50 values of 33.4-52.4 microM against HL-60 (human leukemia), P388 (murine leukemia), and L1210 (murine leukemia) cells. Compound 1 showed melanogenesis inhibitory activity (melanin content 80.0 %) with low cytotoxicity (cell viability 97.6%) at a low concentration (10 microM). |
| 巻・号 | 8(10) |
| ページ | 1367-9 |
| 公開日 | 2013-10-1 |
| PMID | 24354176 |
| MeSH | Animals Antineoplastic Agents, Phytogenic / chemistry Antineoplastic Agents, Phytogenic / isolation & purification* Citrullus / chemistry* Drug Screening Assays, Antitumor HL-60 Cells Humans Mice Molecular Structure Plants, Medicinal / chemistry Seeds / chemistry Triterpenes / chemistry Triterpenes / isolation & purification* |
| IF | 0.468 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Youtube |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | B16 melanoma 4A5(RCB0557) |