Reference - Detail
| RRC ID | 73002 |
|---|---|
| Author | Eguchi T, Kanai S, Kakinuma K, Okazaki T, Mizoue K. |
| Title | Synthesis of NG-061 and its analogs, and their biological evaluation as an enhancer of nerve growth factor. |
| Journal | Chem Pharm Bull (Tokyo) |
| Abstract |
A novel potentiator of nerve growth factor (NGF), NG-061, which had been isolated from the fermentation broth of Penicillium minioluteum F-4627, was synthesized from methoxybenzoquinone and phenylacetylhydrazine in a single step. A series of acyl hydrazone derivatives were also synthesized and their potentiator activity of neurotrophic effect of NGF on neurite outgrowth was evaluated by assay with a rat pheochromocytoma cell line PC12. |
| Volume | 48(10) |
| Pages | 1470-3 |
| Published | 2000-10-1 |
| DOI | 10.1248/cpb.48.1470 |
| PMID | 11045453 |
| MeSH | Animals Drug Evaluation, Preclinical Hydrazines / chemical synthesis* Hydrazines / chemistry Hydrazines / pharmacology Molecular Structure Nerve Growth Factor / agonists* PC12 Cells Phenylacetates / chemical synthesis* Phenylacetates / chemistry Phenylacetates / pharmacology Rats Spectrum Analysis |
| IF | 1.416 |
| Resource | |
| Human and Animal Cells | PC-12(RCB0009) |