| RRC ID |
73160
|
| 著者 |
Shimizu K, Ueda S, Kawamura M, Satoh M, Fujii SI.
|
| タイトル |
A single immunization with cellular vaccine confers dual protection against SARS-CoV-2 and cancer.
|
| ジャーナル |
Cancer Sci
|
| Abstract |
The efficacy of current coronavirus disease 2019 (COVID-19) vaccines has been demonstrated; however, emerging evidence suggests insufficient protection in certain immunocompromised cancer patients. We previously developed a cell-based anti-cancer vaccine platform involving artificial adjuvant vector cells (aAVCs) capable of inducing a strong adaptive response by enhancing the innate immunity. aAVCs are target antigen-transfected allogenic cells that simultaneously express the natural killer T-cell ligand-CD1d complex on their surface. In the present study, we applied this system for targeting the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein (CoV-2-S) using CoV-2-S-expressing aAVCs (aAVC-CoV-2) and evaluated the immune response in a murine model. A single dose of aAVC-CoV-2 induced a large amount of CoV-2-S-specific, multifunctional CTLs in addition to CD4+ T-cell-dependent anti-CoV-2-S-specific Abs. CoV-2-S-specific CTLs infiltrated the lung parenchyma and persisted as long-term memory T cells. Furthermore, we immunized mice with CoV-2-S- and tumor-associated antigen (TAA)-co-expressing aAVCs (aAVC-TAA/CoV-2) and evaluated whether the anti-SARS-CoV-2 and antitumor CTLs were elicited. We found that the aAVC-TAA/CoV-2-S therapy exerted apparent antitumor effects and induced CoV-2-S-specific CTLs. These findings suggest aAVC-TAA/CoV-2-S therapy as a promising vaccine candidate for preventing COVID-19, as well as enhancing the effectiveness of cancer therapies.
|
| 巻・号 |
113(8)
|
| ページ |
2536-2547
|
| 公開日 |
2022-8-1
|
| DOI |
10.1111/cas.15434
|
| PMID |
35598170
|
| PMC |
PMC9348309
|
| MeSH |
Adjuvants, Immunologic
Animals
Antibodies, Neutralizing
Antibodies, Viral
COVID-19* / prevention & control
Immunization
Mice
Neoplasms*
SARS-CoV-2
Vaccination
Viral Vaccines*
|
| IF |
4.966
|
| リソース情報 |
| ヒト・動物細胞 |
NIH3T3 |
