論文 - 詳細
| RRC ID | 73284 |
|---|---|
| 著者 | Hattori EY, Masuda T, Mineharu Y, Mikami M, Terada Y, Matsui Y, Kubota H, Matsuo H, Hirata M, Kataoka TR, Nakahata T, Ikeda S, Miyamoto S, Sugiyama H, Arakawa Y, Kamikubo Y. |
| タイトル | A RUNX-targeted gene switch-off approach modulates the BIRC5/PIF1-p21 pathway and reduces glioblastoma growth in mice. |
| ジャーナル | Commun Biol |
| Abstract |
Glioblastoma is the most common adult brain tumour, representing a high degree of malignancy. Transcription factors such as RUNX1 are believed to be involved in the malignancy of glioblastoma. RUNX1 functions as an oncogene or tumour suppressor gene with diverse target genes. Details of the effects of RUNX1 on the acquisition of malignancy in glioblastoma remain unclear. Here, we show that RUNX1 downregulates p21 by enhancing expressions of BIRC5 and PIF1, conferring anti-apoptotic properties on glioblastoma. A gene switch-off therapy using alkylating agent-conjugated pyrrole-imidazole polyamides, designed to fit the RUNX1 DNA groove, decreased expression levels of BIRC5 and PIF1 and induced apoptosis and cell cycle arrest via p21. The RUNX1-BIRC5/PIF1-p21 pathway appears to reflect refractory characteristics of glioblastoma and thus holds promise as a therapeutic target. RUNX gene switch-off therapy may represent a novel treatment for glioblastoma. |
| 巻・号 | 5(1) |
| ページ | 939 |
| 公開日 | 2022-9-9 |
| DOI | 10.1038/s42003-022-03917-5 |
| PII | 10.1038/s42003-022-03917-5 |
| PMID | 36085167 |
| PMC | PMC9463152 |
| MeSH | Animals Apoptosis / genetics Brain Neoplasms* / genetics Core Binding Factor Alpha 2 Subunit DNA Helicases Glioblastoma* / genetics Mice Oncogenes |
| IF | 4.165 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 7 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 遺伝子材料 | pENTR4-H1tetOx1 (RDB07916) CS-RfA-ETV (RDB08020) CS-RfA-ETBsd (RDB07917) |