論文 - 詳細
| RRC ID | 73319 |
|---|---|
| 著者 | Kohsaka H, Zwart MF, Fushiki A, Fetter RD, Truman JW, Cardona A, Nose A. |
| タイトル | Regulation of forward and backward locomotion through intersegmental feedback circuits in Drosophila larvae. |
| ジャーナル | Nat Commun |
| Abstract |
Animal locomotion requires spatiotemporally coordinated contraction of muscles throughout the body. Here, we investigate how contractions of antagonistic groups of muscles are intersegmentally coordinated during bidirectional crawling of Drosophila larvae. We identify two pairs of higher-order premotor excitatory interneurons present in each abdominal neuromere that intersegmentally provide feedback to the adjacent neuromere during motor propagation. The two feedback neuron pairs are differentially active during either forward or backward locomotion but commonly target a group of premotor interneurons that together provide excitatory inputs to transverse muscles and inhibitory inputs to the antagonistic longitudinal muscles. Inhibition of either feedback neuron pair compromises contraction of transverse muscles in a direction-specific manner. Our results suggest that the intersegmental feedback neurons coordinate contraction of synergistic muscles by acting as delay circuits representing the phase lag between segments. The identified circuit architecture also shows how bidirectional motor networks could be economically embedded in the nervous system. |
| 巻・号 | 10(1) |
| ページ | 2654 |
| 公開日 | 2019-6-14 |
| DOI | 10.1038/s41467-019-10695-y |
| PII | 10.1038/s41467-019-10695-y |
| PMID | 31201326 |
| PMC | PMC6572865 |
| MeSH | Animals Animals, Genetically Modified Drosophila Proteins / genetics Drosophila melanogaster / physiology Feedback, Physiological* Interneurons / physiology Larva / physiology Locomotion / physiology* Microscopy, Electron Models, Animal Muscle Contraction / physiology Muscles / innervation Muscles / physiology Nerve Net / physiology* Optogenetics |
| IF | 12.121 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 8 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#118806 DGRC#118811 DGRC#118812 DGRC#118813 DGRC#118814 DGRC#118815 DGRC#118816 |