| RRC ID |
73319
|
| 著者 |
Kohsaka H, Zwart MF, Fushiki A, Fetter RD, Truman JW, Cardona A, Nose A.
|
| タイトル |
Regulation of forward and backward locomotion through intersegmental feedback circuits in Drosophila larvae.
|
| ジャーナル |
Nat Commun
|
| Abstract |
Animal locomotion requires spatiotemporally coordinated contraction of muscles throughout the body. Here, we investigate how contractions of antagonistic groups of muscles are intersegmentally coordinated during bidirectional crawling of Drosophila larvae. We identify two pairs of higher-order premotor excitatory interneurons present in each abdominal neuromere that intersegmentally provide feedback to the adjacent neuromere during motor propagation. The two feedback neuron pairs are differentially active during either forward or backward locomotion but commonly target a group of premotor interneurons that together provide excitatory inputs to transverse muscles and inhibitory inputs to the antagonistic longitudinal muscles. Inhibition of either feedback neuron pair compromises contraction of transverse muscles in a direction-specific manner. Our results suggest that the intersegmental feedback neurons coordinate contraction of synergistic muscles by acting as delay circuits representing the phase lag between segments. The identified circuit architecture also shows how bidirectional motor networks could be economically embedded in the nervous system.
|
| 巻・号 |
10(1)
|
| ページ |
2654
|
| 公開日 |
2019-6-14
|
| DOI |
10.1038/s41467-019-10695-y
|
| PII |
10.1038/s41467-019-10695-y
|
| PMID |
31201326
|
| PMC |
PMC6572865
|
| MeSH |
Animals
Animals, Genetically Modified
Drosophila Proteins / genetics
Drosophila melanogaster / physiology
Feedback, Physiological*
Interneurons / physiology
Larva / physiology
Locomotion / physiology*
Microscopy, Electron
Models, Animal
Muscle Contraction / physiology
Muscles / innervation
Muscles / physiology
Nerve Net / physiology*
Optogenetics
|
| IF |
12.121
|
| リソース情報 |
| ショウジョウバエ |
DGRC#118806
DGRC#118811
DGRC#118812
DGRC#118813
DGRC#118814
DGRC#118815
DGRC#118816 |
