論文 - 詳細
| RRC ID | 73424 |
|---|---|
| 著者 | Ikenaga J, Aratake S, Yoshida K, Yoshida M. |
| タイトル | A novel role for ATP2B in ascidians: Ascidian-specific mutations in ATP2B contribute to sperm chemotaxis. |
| ジャーナル | J Exp Zool B Mol Dev Evol |
| Abstract |
Sperm chemotaxis, in which sperms are attracted to conspecific eggs via species-specific attractants, plays an important role in fertilization. This phenomenon has been observed in various animals and species-specific sperm attractants have been reported in some species. However, the mechanisms involved in the reception and recognition of the species-specific attractant by the sperms is poorly studied. Previously, we found that the plasma membrane-type Ca2+ /ATPase (PMCA) is the receptor for the sperm-activating and -attracting factor (SAAF) in the ascidian Ciona intestinalis. To determine the role of PMCA in species-specific sperm chemotaxis, we identified the amino acid sequences of PMCAs derived from six Phlebobranchia species. The testis-specific splice variant of PMCA was found to be present in all the species investigated and the ascidian-specific sequence was detected near the 3'-terminus. Moreover, dN/dS analysis revealed that the extracellular loops 1, 2, and 4 in ascidian PMCA underwent a positive selection. These findings suggest that PMCA recognizes the species-specific structure of SAAF at the extracellular loops 1, 2, and 4, and its testis-specific C-terminal region is involved in the activation and chemotaxis of ascidian sperms. |
| 巻・号 | 338(7) |
| ページ | 430-437 |
| 公開日 | 2022-11-1 |
| DOI | 10.1002/jez.b.23133 |
| PMID | 35468255 |
| MeSH | Adenosine Triphosphatases Animals Chemotaxis / physiology Ciona intestinalis* / genetics Male Mutation Semen Sperm Motility / physiology Spermatozoa Urochordata* / genetics |
| IF | 1.897 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Peer-review(Publons) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| カタユウレイボヤ・(ニッポンウミシダ) | Wild C. int |