論文 - 詳細
| RRC ID | 73801 |
|---|---|
| 著者 | Liu S, Baeg GH, Yang Y, Goh FG, Bao H, Wagner EJ, Yang X, Cai Y. |
| タイトル | The Integrator complex desensitizes cellular response to TGF-β/BMP signaling. |
| ジャーナル | Cell Rep |
| Abstract |
Maintenance of stem cells requires the concerted actions of niche-derived signals and stem cell-intrinsic factors. Although Decapentaplegic (Dpp), a Drosophila bone morphogenetic protein (BMP) molecule, can act as a long-range morphogen, its function is spatially limited to the germline stem cell niche in the germarium. We show here that Integrator, a complex known to be involved in RNA polymerase II (RNAPII)-mediated transcriptional regulation in the nucleus, promotes germline differentiation by restricting niche-derived Dpp/BMP activity in the cytoplasm. Further results show that Integrator works in various developmental contexts to desensitize the cellular response to Dpp/BMP signaling during Drosophila development. Mechanistically, our results show that Integrator forms a multi-subunit complex with the type I receptor Thickveins (Tkv) and other Dpp/BMP signaling components and acts in a negative feedback loop to promote Tkv turnover independent of its transcriptional activity. Similarly, human Integrator subunits bind transforming growth factor β (TGF-β)/BMP signaling components and antagonize their activity, suggesting a conserved role of Integrator across metazoans. |
| 巻・号 | 42(1) |
| ページ | 112007 |
| 公開日 | 2023-1-31 |
| DOI | 10.1016/j.celrep.2023.112007 |
| PII | S2211-1247(23)00018-9 |
| PMID | 36641752 |
| MeSH | Animals Bone Morphogenetic Proteins / metabolism Cell Differentiation / physiology Drosophila / metabolism Drosophila Proteins* / genetics Drosophila Proteins* / metabolism Humans Protein Serine-Threonine Kinases / metabolism Receptors, Cell Surface / metabolism Signal Transduction / physiology Transforming Growth Factor beta* / metabolism |
| IF | 8.109 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 9 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | |