Reference - Detail
| RRC ID | 73804 |
|---|---|
| Author | Moriyama T, Kataoka H, Hamasuna R, Yokogami K, Uehara H, Kawano H, Goya T, Tsubouchi H, Koono M, Wakisaka S. |
| Title | Up-regulation of vascular endothelial growth factor induced by hepatocyte growth factor/scatter factor stimulation in human glioma cells. |
| Journal | Biochem Biophys Res Commun |
| Abstract |
Recent findings suggest that hepatocyte growth factor/scatter factor (HGF/SF) contributes to the malignant progression of human gliomas. We investigated the effect of HGF/SF on vascular endothelial growth factor (VEGF) expression of c-Met/HGF receptor-positive human glioma cell lines. Treatment of the glioma cells with various concentrations of HGF/SF resulted in an enhanced secretion of VEGF proteins accompanying increased transcription of VEGF mRNA in a dose-dependent fashion. Since malignant gliomas frequently co-express HGF/SF and its receptor, these results suggest that HGF/SF could act as an indirect angiogenic factor through autocrine induction of VEGF expression and secretion in malignant gliomas. |
| Volume | 249(1) |
| Pages | 73-7 |
| Published | 1998-8-10 |
| DOI | 10.1006/bbrc.1998.9078 |
| PII | S0006-291X(98)99078-7 |
| PMID | 9705834 |
| MeSH | Endothelial Growth Factors / biosynthesis* Glioma / metabolism* Hepatocyte Growth Factor / pharmacology* Humans Lymphokines / biosynthesis* Tumor Cells, Cultured Up-Regulation / drug effects Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors |
| IF | 2.985 |
| Resource | |
| Human and Animal Cells | KG-1-C(RCB0270) |