論文 - 詳細
| RRC ID | 74006 |
|---|---|
| 著者 | Lu L, Kuroishi T, Tanaka Y, Furukawa M, Nochi T, Sugawara S. |
| タイトル | Differential expression of CD11c defines two types of tissue-resident macrophages with different origins in steady-state salivary glands. |
| ジャーナル | Sci Rep |
| Abstract |
Gland macrophages are primed for gland development and functions through interactions within their niche. However, the phenotype, ontogeny, and function of steady-state salivary gland (SG) macrophages remain unclear. We herein identified CD11c+ and CD11c- subsets among CD64+ macrophages in steady-state murine SGs. CD11c- macrophages were predominant in the SGs of embryonic and newborn mice and decreased with advancing age. CD11c+ macrophages were rarely detected in the embryonic period, but rapidly expanded after birth. CD11c+, but not CD11c-, macrophage numbers decreased in mice treated with a CCR2 antagonist, suggesting that CD11c+ macrophages accumulate from bone marrow-derived progenitors in a CCR2-dependent manner, whereas CD11c- macrophages were derived from embryonic progenitors in SGs. CD11c+ and CD11c- macrophages strongly expressed colony-stimulating factor (CSF)-1 receptor, the injection of an anti-CSF-1 receptor blocking antibody markedly reduced both subsets, and SGs strongly expressed CSF-1, indicating the dependency of SG resident macrophage development on CSF-1. The phagocytic activity of SG macrophages was extremely weak; however, the gene expression profile of SG macrophages indicated that SG macrophages regulate gland development and functions in SGs. These results suggest that SG CD11c+ and CD11c- macrophages are developed and instructed to perform SG-specific functions in steady-state SGs. |
| 巻・号 | 12(1) |
| ページ | 931 |
| 公開日 | 2022-1-18 |
| DOI | 10.1038/s41598-022-04941-5 |
| PII | 10.1038/s41598-022-04941-5 |
| PMID | 35042931 |
| PMC | PMC8766464 |
| MeSH | Animals CD11 Antigens / genetics* CD11 Antigens / metabolism CD11c Antigen / genetics CD11c Antigen / metabolism Cell Differentiation Dendritic Cells / immunology Female Gene Expression / genetics Gene Expression Regulation, Developmental / genetics Macrophage Colony-Stimulating Factor / metabolism Macrophages / immunology Macrophages / metabolism* Male Mice / embryology Mice, Inbred C57BL Phagocytes / metabolism Salivary Glands / immunology Salivary Glands / metabolism* |
| IF | 3.998 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 11 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | AFS98(RCB4486) |
| 実験動物マウス | RBRC00144 |