論文 - 詳細
| RRC ID | 74136 |
|---|---|
| 著者 | Tomihara K, Kawamoto M, Suzuki Y, Katsuma S, Kiuchi T. |
| タイトル | Masculinizer-induced dosage compensation is achieved by transcriptional downregulation of both copies of Z-linked genes in the silkworm, Bombyx mori. |
| ジャーナル | Biol Lett |
| Abstract |
The evolution of dosage compensation produces similar expression of sex-linked and autosomal genes in the heterogametic sex. The silkworm (Bombyx mori), a lepidopteran insect, has a female heterogametic WZ sex determination system. A Z-linked gene, Masculinizer (Masc), is the primary determinant of maleness and dosage compensation in B. mori. However, it remains unknown whether one of the two Z chromosomes is inactivated or both Z chromosomes are suppressed in B. mori males. Hence, we performed transcriptome analysis using hybrids between two B. mori strains and analysed allele-specific expression to distinguish these alternatives. Our analysis revealed that genes on both the maternal and paternal Z chromosomes are transcriptionally upregulated in Masc knocked down males. We therefore conclude that both Z chromosomes are transcriptionally downregulated in B. mori males, similar to the system in Caenorhabditis elegans. |
| 巻・号 | 18(9) |
| ページ | 20220116 |
| 公開日 | 2022-9-1 |
| DOI | 10.1098/rsbl.2022.0116 |
| PMID | 36069069 |
| PMC | PMC9449812 |
| MeSH | Animals Bombyx* / genetics Bombyx* / metabolism Dosage Compensation, Genetic Down-Regulation Female Insect Proteins / genetics Insect Proteins / metabolism Male Sex Chromosomes / genetics Sex Chromosomes / metabolism |
| IF | 2.869 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 10 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| カイコ | n03 p50 |