Reference - Detail
| RRC ID | 74272 |
|---|---|
| Author | Watanabe Y, Yoshida Y, Tokiwa T, Higo M, Ban S, Ikeda A, Noguchi Y, Hirose T, Sunazuka T, Nonaka K, Yaguchi T, Iwatsuki M. |
| Title | Hakuhybotric acid, a new antifungal polyketide produced by a mycoparasitic fungus Hypomyces pseudocorticiicola FKI-9008. |
| Journal | J Gen Appl Microbiol |
| Abstract |
A new antifungal polyketide, named hakuhybotric acid (1), was isolated from a cultured broth of a mycoparasitic fungus Hypomyces pseudocorticiicola FKI-9008, together with two known analogs, F2928-1 (2) and Cladobotric acid E (3). Their structures were elucidated by MS and NMR analyses. Hakuhybotric acid was a new analog of Cladobotric acid where two epoxy groups in F2928-1 were replaced with olefins. All compounds showed antifungal activity against four different species of Aspergillus spp., the causative agents of aspergillosis. It was suggested that mycoparasitic fungi are a useful source to search antifungal drug lead compounds. |
| Volume | 68(4) |
| Pages | 200-206 |
| Published | 2022-11-22 |
| DOI | 10.2323/jgam.2022.03.002 |
| PMID | 35598981 |
| MeSH | Antifungal Agents / chemistry Antifungal Agents / pharmacology Hypocreales* Microbial Sensitivity Tests Polyketides* / pharmacology |
| IF | 1.442 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Pathogenic eukaryotic microorganisms | Aspergillus fumigatus IFM 61493, Aspergillus lentulus IFM 62073, Aspergillus felis IFM 62093, Aspergillus udagawae IFM 62100 |