| RRC ID |
74272
|
| Author |
Watanabe Y, Yoshida Y, Tokiwa T, Higo M, Ban S, Ikeda A, Noguchi Y, Hirose T, Sunazuka T, Nonaka K, Yaguchi T, Iwatsuki M.
|
| Title |
Hakuhybotric acid, a new antifungal polyketide produced by a mycoparasitic fungus Hypomyces pseudocorticiicola FKI-9008.
|
| Journal |
J Gen Appl Microbiol
|
| Abstract |
A new antifungal polyketide, named hakuhybotric acid (1), was isolated from a cultured broth of a mycoparasitic fungus Hypomyces pseudocorticiicola FKI-9008, together with two known analogs, F2928-1 (2) and Cladobotric acid E (3). Their structures were elucidated by MS and NMR analyses. Hakuhybotric acid was a new analog of Cladobotric acid where two epoxy groups in F2928-1 were replaced with olefins. All compounds showed antifungal activity against four different species of Aspergillus spp., the causative agents of aspergillosis. It was suggested that mycoparasitic fungi are a useful source to search antifungal drug lead compounds.
|
| Volume |
68(4)
|
| Pages |
200-206
|
| Published |
2022-11-22
|
| DOI |
10.2323/jgam.2022.03.002
|
| PMID |
35598981
|
| MeSH |
Antifungal Agents / chemistry
Antifungal Agents / pharmacology
Hypocreales*
Microbial Sensitivity Tests
Polyketides* / pharmacology
|
| IF |
1.442
|
| Resource |
| Pathogenic eukaryotic microorganisms |
Aspergillus fumigatus IFM 61493, Aspergillus lentulus IFM 62073, Aspergillus felis IFM 62093, Aspergillus udagawae IFM 62100 |
