論文 - 詳細
| RRC ID | 74272 |
|---|---|
| 著者 | Watanabe Y, Yoshida Y, Tokiwa T, Higo M, Ban S, Ikeda A, Noguchi Y, Hirose T, Sunazuka T, Nonaka K, Yaguchi T, Iwatsuki M. |
| タイトル | Hakuhybotric acid, a new antifungal polyketide produced by a mycoparasitic fungus Hypomyces pseudocorticiicola FKI-9008. |
| ジャーナル | J Gen Appl Microbiol |
| Abstract |
A new antifungal polyketide, named hakuhybotric acid (1), was isolated from a cultured broth of a mycoparasitic fungus Hypomyces pseudocorticiicola FKI-9008, together with two known analogs, F2928-1 (2) and Cladobotric acid E (3). Their structures were elucidated by MS and NMR analyses. Hakuhybotric acid was a new analog of Cladobotric acid where two epoxy groups in F2928-1 were replaced with olefins. All compounds showed antifungal activity against four different species of Aspergillus spp., the causative agents of aspergillosis. It was suggested that mycoparasitic fungi are a useful source to search antifungal drug lead compounds. |
| 巻・号 | 68(4) |
| ページ | 200-206 |
| 公開日 | 2022-11-22 |
| DOI | 10.2323/jgam.2022.03.002 |
| PMID | 35598981 |
| MeSH | Antifungal Agents / chemistry Antifungal Agents / pharmacology Hypocreales* Microbial Sensitivity Tests Polyketides* / pharmacology |
| IF | 1.442 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 病原真核微生物 | Aspergillus fumigatus IFM 61493, Aspergillus lentulus IFM 62073, Aspergillus felis IFM 62093, Aspergillus udagawae IFM 62100 |