論文 - 詳細
| RRC ID | 74300 |
|---|---|
| 著者 | Yukiko Ogino, Satoshi Ansai, Eiji Watanabe, Masaki Yasugi, Yukitoshi Katayama, Hirotaka Sakamoto, Keigo Okamoto, Kataaki Okubo, Yasuhiro Yamamoto, Ikuyo Hara, Touko Yamazaki, Ai Kato, Yasuhiro Kamei, Kiyoshi Naruse, Kohei Ohta, Hajime Ogino, Tatsuya Sakamoto, Shinichi Miyagawa, Tomomi Sato, Gen Yamada, Michael E. Baker, Taisen Iguchi |
| タイトル | Evolutionary differentiation of androgen receptor is responsible for sexual characteristic development in a teleost fish |
| ジャーナル | Nature Communications |
| Abstract |
Teleost fishes exhibit complex sexual characteristics in response to androgens, such as fin enlargement and courtship display. However, the molecular mechanisms underlying their evolutionary acquisition remain largely unknown. To address this question, we analyse medaka (Oryzias latipes) mutants deficient in teleost-specific androgen receptor ohnologs (ara and arb). We discovered that neither ar ohnolog was required for spermatogenesis, whilst they appear to be functionally redundant for the courtship display in males. However, both were required for reproductive success: ara for tooth enlargement and the reproductive behaviour eliciting female receptivity, arb for male-specific fin morphogenesis and sexual motivation. We further showed that differences between the two ar ohnologs in their transcription, cellular localisation of their encoded proteins, and their downstream genetic programmes could be responsible for the phenotypic diversity between the ara and arb mutants. These findings suggest that the ar ohnologs have diverged in two ways: first, through the loss of their roles in spermatogenesis and second, through gene duplication followed by functional differentiation that has likely resolved the pleiotropic roles derived from their ancestral gene. Thus, our results provide insights into how genome duplication impacts the massive diversification of sexual characteristics in the teleost lineage. |
| 巻・号 | 14 |
| 公開日 | 2023-3-14 |
| DOI | 10.1038/s41467-023-37026-6 |
| PMID | 36918573 |
| PMC | PMC10014959 |
| MeSH | Angiotensin Receptor Antagonists Angiotensin-Converting Enzyme Inhibitors Animals Biological Evolution Evolution, Molecular Female Fishes / genetics Fishes / metabolism Male Oryzias* / genetics Oryzias* / metabolism Receptors, Androgen* / genetics Receptors, Androgen* / metabolism |
| IF | 12.121 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 39 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| メダカ | Cab (MT830) TILLING_MUTANT (TA5383) TILLING_MUTANT (TA3793) ara^3xFLAG-2A-mClover3 (TG1341) arb^3xFLAG-2A-mClover3 (TG1342) Ara(del1) (MT1560) Arb(del10) (MT1561) |