論文 - 詳細
| RRC ID | 74595 |
|---|---|
| 著者 | Liang Y, Furukawa H, Sakamoto K, Inaba H, Matsuura K. |
| タイトル | Anticancer Activity of Reconstituted Ribonuclease S-Decorated Artificial Viral Capsid. |
| ジャーナル | Chembiochem |
| Abstract |
Ribonuclease S (RNase S) is an enzyme that exhibits anticancer activity by degrading RNAs within cancer cells; however, the cellular uptake efficiency is low due to its small molecular size. Here we generated RNase S-decorated artificial viral capsids with a size of 70-170 nm by self-assembly of the β-annulus-S-peptide followed by reconstitution with S-protein at neutral pH. The RNase S-decorated artificial viral capsids are efficiently taken up by HepG2 cells and exhibit higher RNA degradation activity in cells compared with RNase S alone. Cell viability assays revealed that RNase S-decorated capsids have high anticancer activity comparable to that of standard anticancer drugs. |
| 巻・号 | 23(15) |
| ページ | e202200220 |
| 公開日 | 2022-8-3 |
| DOI | 10.1002/cbic.202200220 |
| PMID | 35676201 |
| PMC | PMC9400862 |
| MeSH | Capsid* Capsid Proteins / chemistry Peptides / chemistry Ribonucleases* / pharmacology |
| IF | 2.576 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 13 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | Hep G2 |