| RRC ID |
74620
|
| 著者 |
Morishita Y, Tsukada K, Murakami K, Irie K, Asai T.
|
| タイトル |
Synthetic Biology-Based Discovery of Diterpenoid Pyrones from the Genome of Eupenicillium shearii.
|
| ジャーナル |
J Nat Prod
|
| Abstract |
Diterpenoid pyrones are a type of mainly fungal meroterpenoid metabolite consisting of a diterpene connected to a pyrone, some of which show potent bioactivity. Through genome mining and heterologous expression, nine new diterpenoid pyrones, shearones A-I (1-9), were discovered from the fungus Eupenicillium shearii IFM 42152, and their biosynthetic enzyme activities were revealed. Some of these heterologously biosynthesized diterpenoid pyrones exhibited moderate antiaggregative ability against amyloid β42 in vitro.
|
| 巻・号 |
85(2)
|
| ページ |
384-390
|
| 公開日 |
2022-2-25
|
| DOI |
10.1021/acs.jnatprod.1c00973
|
| PMID |
35057611
|
| MeSH |
Diterpenes* / metabolism
Diterpenes* / pharmacology
Penicillium
Pyrones* / pharmacology
Synthetic Biology
|
| IF |
3.782
|
| リソース情報 |
| 病原真核微生物 |
Eupenicillium shearii IFM 42152 |
