論文 - 詳細
| RRC ID | 74648 |
|---|---|
| 著者 | Li Y, Dong P, Yang Y, Guo T, Zhao Q, Miao D, Li H, Lu T, Xia F, Lyu J, Ma J, Kornberg TB, Zhang Q, Huang H. |
| タイトル | Metabolic control of progenitor cell propagation during Drosophila tracheal remodeling. |
| ジャーナル | Nat Commun |
| Abstract |
Adult progenitor cells in the trachea of Drosophila larvae are activated and migrate out of niches when metamorphosis induces tracheal remodeling. Here we show that in response to metabolic deficiency in decaying tracheal branches, signaling by the insulin pathway controls the progenitor cells by regulating Yorkie (Yki)-dependent proliferation and migration. Yki, a transcription coactivator that is regulated by Hippo signaling, promotes transcriptional activation of cell cycle regulators and components of the extracellular matrix in tracheal progenitor cells. These findings reveal that regulation of Yki signaling by the insulin pathway governs proliferation and migration of tracheal progenitor cells, thereby identifying the regulatory mechanism by which metabolic depression drives progenitor cell activation and cell division that underlies tracheal remodeling. |
| 巻・号 | 13(1) |
| ページ | 2817 |
| 公開日 | 2022-5-20 |
| DOI | 10.1038/s41467-022-30492-4 |
| PII | 10.1038/s41467-022-30492-4 |
| PMID | 35595807 |
| PMC | PMC9122933 |
| MeSH | Animals Cell Proliferation Drosophila / metabolism Drosophila Proteins* / genetics Drosophila Proteins* / metabolism Drosophila melanogaster / metabolism Insulins* / metabolism Intracellular Signaling Peptides and Proteins / metabolism Nuclear Proteins / metabolism Protein Serine-Threonine Kinases Stem Cells / metabolism Trachea / metabolism Trans-Activators / metabolism |
| IF | 12.121 |
| リソース情報 | |
| ショウジョウバエ | DGRC#115511 |