論文 - 詳細
| RRC ID | 74671 |
|---|---|
| 著者 | Lapraz F, Boutres C, Fixary-Schuster C, De Queiroz BR, Plaçais PY, Cerezo D, Besse F, Préat T, Noselli S. |
| タイトル | Asymmetric activity of NetrinB controls laterality of the Drosophila brain. |
| ジャーナル | Nat Commun |
| Abstract |
Left-Right (LR) asymmetry of the nervous system is widespread across animals and is thought to be important for cognition and behaviour. But in contrast to visceral organ asymmetry, the genetic basis and function of brain laterality remain only poorly characterized. In this study, we performed RNAi screening to identify genes controlling brain asymmetry in Drosophila. We found that the conserved NetrinB (NetB) pathway is required for a small group of bilateral neurons to project asymmetrically into a pair of neuropils (Asymmetrical Bodies, AB) in the central brain in both sexes. While neurons project unilaterally into the right AB in wild-type flies, netB mutants show a bilateral projection phenotype and hence lose asymmetry. Developmental time course analysis reveals an initially bilateral connectivity, eventually resolving into a right asymmetrical circuit during metamorphosis, with the NetB pathway being required just prior symmetry breaking. We show using unilateral clonal analysis that netB activity is required specifically on the right side for neurons to innervate the right AB. We finally show that loss of NetB pathway activity leads to specific alteration of long-term memory, providing a functional link between asymmetrical circuitry determined by NetB and animal cognitive functions. |
| 巻・号 | 14(1) |
| ページ | 1052 |
| 公開日 | 2023-2-24 |
| DOI | 10.1038/s41467-023-36644-4 |
| PII | 10.1038/s41467-023-36644-4 |
| PMID | 36828820 |
| PMC | PMC9958012 |
| MeSH | Animals Body Patterning / genetics Brain / metabolism Drosophila* / metabolism Drosophila Proteins* / metabolism Female Functional Laterality / physiology Male Nerve Growth Factors / metabolism Neuropil / metabolism |
| IF | 12.121 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 10 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#115011 |