| RRC ID |
74685
|
| 著者 |
Saha B, Acharjee S, Ghosh G, Dasgupta P, Prasad M.
|
| タイトル |
Germline protein, Cup, non-cell autonomously limits migratory cell fate in Drosophila oogenesis.
|
| ジャーナル |
PLoS Genet
|
| Abstract |
Specification of migratory cell fate from a stationary population is complex and indispensable both for metazoan development as well for the progression of the pathological condition like tumor metastasis. Though this cell fate transformation is widely prevalent, the molecular understanding of this phenomenon remains largely elusive. We have employed the model of border cells (BC) in Drosophila oogenesis and identified germline activity of an RNA binding protein, Cup that limits acquisition of migratory cell fate from the neighbouring follicle epithelial cells. As activation of JAK-STAT in the follicle cells is critical for BC specification, our data suggest that Cup, non-cell autonomously restricts the domain of JAK-STAT by activating Notch in the follicle cells. Employing genetics and Delta endocytosis assay, we demonstrate that Cup regulates Delta recycling in the nurse cells through Rab11GTPase thus facilitating Notch activation in the adjacent follicle cells. Since Notch and JAK-STAT are antagonistic, we propose that germline Cup functions through Notch and JAK-STAT to modulate BC fate specification from their static epithelial progenitors.
|
| 巻・号 |
19(2)
|
| ページ |
e1010631
|
| 公開日 |
2023-2-1
|
| DOI |
10.1371/journal.pgen.1010631
|
| PII |
PGENETICS-D-22-01290
|
| PMID |
36791149
|
| PMC |
PMC9974129
|
| MeSH |
Animals
Drosophila* / metabolism
Drosophila Proteins* / genetics
Drosophila Proteins* / metabolism
Drosophila melanogaster / genetics
Drosophila melanogaster / metabolism
Germ Cells / metabolism
Oogenesis / genetics
STAT Transcription Factors / genetics
STAT Transcription Factors / metabolism
Signal Transduction / genetics
|
| IF |
5.175
|
| リソース情報 |
| ショウジョウバエ |
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