論文 - 詳細
| RRC ID | 74716 |
|---|---|
| 著者 | Orr BO, Fetter RD, Davis GW. |
| タイトル | Activation and expansion of presynaptic signaling foci drives presynaptic homeostatic plasticity. |
| ジャーナル | Neuron |
| Abstract |
Presynaptic homeostatic plasticity (PHP) adaptively regulates synaptic transmission in health and disease. Despite identification of numerous genes that are essential for PHP, we lack a dynamic framework to explain how PHP is initiated, potentiated, and limited to achieve precise control of vesicle fusion. Here, utilizing both mice and Drosophila, we demonstrate that PHP progresses through the assembly and physical expansion of presynaptic signaling foci where activated integrins biochemically converge with trans-synaptic Semaphorin2b/PlexinB signaling. Each component of the identified signaling complexes, including alpha/beta-integrin, Semaphorin2b, PlexinB, talin, and focal adhesion kinase (FAK), and their biochemical interactions, are essential for PHP. Complex integrity requires the Sema2b ligand and complex expansion includes a ∼2.5-fold expansion of active-zone associated puncta composed of the actin-binding protein talin. Finally, complex pre-expansion is sufficient to accelerate the rate and extent of PHP. A working model is proposed incorporating signal convergence with dynamic molecular assemblies that instruct PHP. |
| 巻・号 | 110(22) |
| ページ | 3743-3759.e6 |
| 公開日 | 2022-11-16 |
| DOI | 10.1016/j.neuron.2022.08.016 |
| PII | S0896-6273(22)00748-6 |
| PMID | 36087584 |
| PMC | PMC9671843 |
| MeSH | Animals Drosophila / metabolism Drosophila Proteins* / genetics Drosophila Proteins* / metabolism Drosophila melanogaster / physiology Mice Neuronal Plasticity / physiology Presynaptic Terminals / metabolism Talin / metabolism |
| IF | 14.415 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 10 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.2 |
| リソース情報 | |
| ショウジョウバエ | DGRC#115524 |