論文 - 詳細
| RRC ID | 74849 |
|---|---|
| 著者 | Li W, Miyashita A, Sekimizu K. |
| タイトル | Peanut triacylglycerols activate innate immunity both in insects and mammals. |
| ジャーナル | Sci Rep |
| Abstract |
In this study, we investigated immunoreactivity of peanut (Arachis hypogaea) oil using the silkworm (Bombyx mori) model. The peanut oil induced melanin formation when injected to the silkworm hemocoel. We then purified the active substance and identified the triacylglycerols (TAGs) as the responsible molecule for the melanin-forming effect of peanut oil. Also, the peanut TAGs induced the muscle contraction of the silkworm (i.e., cleavage of the insect cytokine BmPP) and the TNF-α production by cultured mouse macrophage cells. The muscle contraction activity of the peanut TAGs was reduced by saponification reaction, indicating that the TAG (not the degraded fatty acids) moiety is responsible for the activity. The muscle contraction effects of other TAGs of olive, lard, and beef oil were comparable with that of peanut TAGs. Nevertheless, for the melanin formation, the effect of peanut TAGs was outstanding. The fatty acid composition of peanut TAGs was distinct from that of olive TAGs. These results suggest that TAGs are immunoreactive and induces cytokines both in insect and mammalian immune systems. Also, the differential effects of peanut and olive TAGs for the melanin formation may suggest that TAGs with different fatty acid compositions are distinguished by the immune system. |
| 巻・号 | 12(1) |
| ページ | 7464 |
| 公開日 | 2022-5-6 |
| DOI | 10.1038/s41598-022-11494-0 |
| PII | 10.1038/s41598-022-11494-0 |
| PMID | 35523841 |
| PMC | PMC9076670 |
| MeSH | Animals Arachis* / metabolism Cattle Fatty Acids / metabolism Immunity, Innate Insecta / metabolism Mammals / metabolism Melanins* / metabolism Mice Peanut Oil / metabolism Triglycerides / metabolism |
| IF | 3.998 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | RAW 264(RCB0535) |