論文 - 詳細
| RRC ID | 74997 |
|---|---|
| 著者 | Kato H, Nemoto K, Shimizu M, Abe A, Asai S, Ishihama N, Matsuoka S, Daimon T, Ojika M, Kawakita K, Onai K, Shirasu K, Yoshida M, Ishiura M, Takemoto D, Takano Y, Terauchi R. |
| タイトル | Recognition of pathogen-derived sphingolipids in Arabidopsis. |
| ジャーナル | Science |
| Abstract |
In plants, many invading microbial pathogens are recognized by cell-surface pattern recognition receptors, which induce defense responses. Here, we show that the ceramide Phytophthora infestans-ceramide D (Pi-Cer D) from the plant pathogenic oomycete P. infestans triggers defense responses in Arabidopsis. Pi-Cer D is cleaved by an Arabidopsis apoplastic ceramidase, NEUTRAL CERAMIDASE 2 (NCER2), and the resulting 9-methyl-branched sphingoid base is recognized by a plasma membrane lectin receptor-like kinase, RESISTANT TO DFPM-INHIBITION OF ABSCISIC ACID SIGNALING 2 (RDA2). 9-Methyl-branched sphingoid base is specific to microbes and induces plant immune responses by physically interacting with RDA2. Loss of RDA2 or NCER2 function compromised Arabidopsis resistance against an oomycete pathogen. Thus, we elucidated the recognition mechanisms of pathogen-derived lipid molecules in plants. |
| 巻・号 | 376(6595) |
| ページ | 857-860 |
| 公開日 | 2022-5-20 |
| DOI | 10.1126/science.abn0650 |
| PMID | 35587979 |
| MeSH | Arabidopsis* / genetics Arabidopsis* / immunology Arabidopsis* / microbiology Arabidopsis Proteins* / genetics Arabidopsis Proteins* / metabolism Ceramides* / metabolism Host-Pathogen Interactions* Neutral Ceramidase* / genetics Neutral Ceramidase* / metabolism Phytophthora infestans* / pathogenicity Plant Diseases* / immunology Plant Diseases* / microbiology Protein Serine-Threonine Kinases / genetics Protein Serine-Threonine Kinases / metabolism Receptors, Mitogen / genetics Receptors, Mitogen / metabolism |
| IF | 41.846 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 132 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| カイコ | d17 |