| RRC ID |
75470
|
| 著者 |
Chen Y, Wei Y, Cai B, Zhou D, Qi D, Zhang M, Zhao Y, Li K, Wedge DE, Pan Z, Xie J, Wang W.
|
| タイトル |
Discovery of Niphimycin C from Streptomyces yongxingensis sp. nov. as a Promising Agrochemical Fungicide for Controlling Banana Fusarium Wilt by Destroying the Mitochondrial Structure and Function.
|
| ジャーナル |
J Agric Food Chem
|
| Abstract |
Banana Fusarium wilt caused by Fusarium oxysporum f. sp. cubense (Foc) is the most destructive soil-borne fungal disease. Tropical race 4 (Foc TR4), one of the strains of Foc, can infect many commercial cultivars, which represents a threat to global banana production. Currently, there are hardly any effective chemical fungicides to control the disease. To search for natural product-based fungicides for controlling banana Fusarium wilt, we identified a novel strain Streptomyces yongxingensis sp. nov. (JCM 34965) from a marine soft coral, from which a bioactive compound, niphimycin C, was isolated using an activity-guided method. Niphimycin C exhibited a strong antifungal activity against Foc TR4 with a value of 1.20 μg/mL for EC50 and obviously inhibited the mycelial growth and spore germination of Foc TR4. It caused the functional loss of mitochondria and the disorder of metabolism of Foc TR4 cells. Further study showed that niphimycin C reduced key enzyme activities of the tricarboxylic acid (TCA) cycle and the electron transport chain (ETC). It displayed broad-spectrum antifungal activities against the selected 12 phytopathogenic fungi. In pot experiments, niphimycin C reduced the disease indexes in banana plantlets and inhibited the infection of Foc TR4 in roots. Hence, niphimycin C could be a promising agrochemical fungicide for the management of fungal diseases.
|
| 巻・号 |
70(40)
|
| ページ |
12784-12795
|
| 公開日 |
2022-10-12
|
| DOI |
10.1021/acs.jafc.2c02810
|
| PMID |
36170206
|
| MeSH |
Agrochemicals
Antifungal Agents / pharmacology
Biological Products*
Fungicides, Industrial* / pharmacology
Fusarium* / genetics
Gene Expression Profiling
Guanidines
Mitochondria
Musa* / genetics
Plant Diseases / microbiology
Plant Diseases / prevention & control
Soil
Streptomyces*
Tricarboxylic Acids
|
| リソース情報 |
| 一般微生物 |
JCM 34965 |
