論文 - 詳細
| RRC ID | 75580 |
|---|---|
| 著者 | Kondo T, Yasui C, Miyajima I, Banno T, Asakura K, Fukuoka T, Ushimaru K, Koga M, Saika A, Morita T, Takahashi Y, Hayashi C, Igarashi M, Takahashi D, Toshima K. |
| タイトル | Synthesis of Mannosylerythritol Lipid Analogues and their Self-Assembling Properties, Recovery Effects on Damaged Skin Cells, and Antibacterial Activity. |
| ジャーナル | Chemistry |
| Abstract |
Synthesis of three types of purpose-designed mannosylerythritol lipid (MEL)-D analogues with decanoyl groups, β-GlcEL-D, α-GlcEL-D, and α-MEL-D, was accomplished utilizing our boron-mediated aglycon delivery (BMAD) methods. Their self-assembling properties, recovery effects on damaged skin cells, and antibacterial activity were evaluated. It was revealed, for the first time, that α-GlcEL-D and α-MEL-D only generated giant vesicles, indicating that slight differences in the steric configuration of an erythritol moiety and fatty acyl chains affect the ability to form vesicles. Analogue α-MEL-D exhibited significant recovery effects on damaged skin cells. Furthermore, α-MEL-D exhibited antibacterial activity as high as that for MEL-D, indicating that α-MEL-D is a promising artificial sugar-based material candidate for enhancing the barrier function of the stratum corneum, superior to a known cosmetic ingredient, and possesses antibacterial activity. |
| 巻・号 | 28(55) |
| ページ | e202201733 |
| 公開日 | 2022-10-4 |
| DOI | 10.1002/chem.202201733 |
| PMID | 35761481 |
| MeSH | Anti-Bacterial Agents / pharmacology Boron* Erythritol Glycolipids Sugars Surface-Active Agents* / pharmacology |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 一般微生物 | JCM 5803 JCM 5804 |