論文 - 詳細
| RRC ID | 75590 |
|---|---|
| 著者 | Ayimbila F, Siriwong S, Nakphaichit M, Keawsompong S. |
| タイトル | In vitro gastrointestinal digestion of Lentinus squarrosulus powder and impact on human fecal microbiota. |
| ジャーナル | Sci Rep |
| Abstract |
Humans have long-used mushrooms as food and medicine, but digestion and colonic fermentation of most mushrooms, including Lentinus squarrosulus is markedly unknown. Here, nutritional profile, digestion and colonic fermentation of L. squarrosulus powder (LP) were determined. The powder contained mainly carbohydrate and protein. SEM and F-TIR analysis of the resistant hydrolysate (RH) revealed that the structure and ratio of carbohydrate and protein components were altered, and released known immunomodulation agents; beta-glucans and mannose. Both LP and RH promoted selected probiotic bacteria, especially Bifidobacterium strains. Using fecal microbiota of five volunteers (V1, V2, V3, V4 and V5), RH stimulated the microbiota of all used volunteers, via decreasing the ratio of Firmicutes/Bacteroidetes ranging from 1.3 to 8.2 times. Also, RH increased the relative abundance of vital immunomodulators; Bacteroides, Bifidobacterium, Clostridium cluster XIVa and IV, and Sutterella. Additionally, RH fermentation enriched the content of branch-chain fatty acids (BCFA) and short-chain fatty acids (SCFA), indicating protein and carbohydrate usage. Notably, propionic and butyric acids were abundant in V1, V2 and V3, while in V4 and V5, acetic and butyric acids were most enriched. Suggesting L. squarrosulus as functional mushroom to improve health and prevent diseases by enhancing gut health. |
| 巻・号 | 12(1) |
| ページ | 2655 |
| 公開日 | 2022-2-16 |
| DOI | 10.1038/s41598-022-06648-z |
| PII | 10.1038/s41598-022-06648-z |
| PMID | 35173256 |
| PMC | PMC8850567 |
| MeSH | Carbohydrates / analysis Digestion / physiology* Fatty Acids / analysis Feces / microbiology* Fermentation Functional Food* / analysis Gastrointestinal Microbiome* Gastrointestinal Tract / physiology* Humans In Vitro Techniques Lentinula* / chemistry Powders Proteins / analysis |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 6 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 一般微生物 | JCM 5810 |