論文 - 詳細
| RRC ID | 75592 |
|---|---|
| 著者 | Yabuuchi S, Oiki S, Minami S, Takase R, Watanabe D, Hashimoto W. |
| タイトル | Enhanced propagation of Granulicatella adiacens from human oral microbiota by hyaluronan. |
| ジャーナル | Sci Rep |
| Abstract |
Host determinants for formation/composition of human oral microbiota remain to be clarified, although microorganisms entering the mouth cannot necessarily colonize the oral environment. Here we show that human oral-abundant bacteria degraded host glycosaminoglycans (GAGs) in saliva and gingiva, and certain bacteria significantly grew on hyaluronan (HA), a kind of GAGs. Microbial communities from teeth or gingiva of healthy donors assimilated HA. Metagenomic analysis of human oral microbiota under different carbon sources revealed HA-driven Granulicatella growth. HA-degrading bacterial strains independently isolated from teeth and gingiva were identified as Granulicatella adiacens producing extracellular 130 kDa polysaccharide lyase as a HA-degrading enzyme encoded in a peculiar GAG genetic cluster containing genes for isomerase KduI and dehydrogenase DhuD. These findings demonstrated that GAGs are one of the host determinants for formation/composition of oral microbiota not only for colonization but also for the adaptation to the host niche. Especially, HA enhanced the G. adiacens propagation. |
| 巻・号 | 12(1) |
| ページ | 10948 |
| 公開日 | 2022-6-29 |
| DOI | 10.1038/s41598-022-14857-9 |
| PII | 10.1038/s41598-022-14857-9 |
| PMID | 35768476 |
| PMC | PMC9243090 |
| MeSH | Bacteria / metabolism Carnobacteriaceae* / metabolism Glycosaminoglycans / metabolism Humans Hyaluronic Acid / metabolism Microbiota* Streptococcus / metabolism |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 一般微生物 | JCM 16131 JCM 1320 JCM 12992 JCM 13448 JCM 16774 JCM 12997 JCM 8152 |