論文 - 詳細
| RRC ID | 75734 |
|---|---|
| 著者 | McCallum S, Obata Y, Fourli E, Boeing S, Peddie CJ, Xu Q, Horswell S, Kelsh RN, Collinson L, Wilkinson D, Pin C, Pachnis V, Heanue TA. |
| タイトル | Enteric glia as a source of neural progenitors in adult zebrafish. |
| ジャーナル | Elife |
| Abstract |
The presence and identity of neural progenitors in the enteric nervous system (ENS) of vertebrates is a matter of intense debate. Here, we demonstrate that the non-neuronal ENS cell compartment of teleosts shares molecular and morphological characteristics with mammalian enteric glia but cannot be identified by the expression of canonical glial markers. However, unlike their mammalian counterparts, which are generally quiescent and do not undergo neuronal differentiation during homeostasis, we show that a relatively high proportion of zebrafish enteric glia proliferate under physiological conditions giving rise to progeny that differentiate into enteric neurons. We also provide evidence that, similar to brain neural stem cells, the activation and neuronal differentiation of enteric glia are regulated by Notch signalling. Our experiments reveal remarkable similarities between enteric glia and brain neural stem cells in teleosts and open new possibilities for use of mammalian enteric glia as a potential source of neurons to restore the activity of intestinal neural circuits compromised by injury or disease. |
| 巻・号 | 9 |
| 公開日 | 2020-8-27 |
| DOI | 10.7554/eLife.56086 |
| PII | 56086 |
| PMID | 32851974 |
| PMC | PMC7521928 |
| MeSH | Animals Brain / cytology Enteric Nervous System / cytology* Mice Neural Stem Cells / cytology Neuroglia / cytology* Receptors, Notch / metabolism Signal Transduction / physiology Zebrafish |
| IF | 7.08 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 24 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ゼブラフィッシュ | SAGFF(LF)234A, UAS:GFP, SAGFF(LF)217B |