論文 - 詳細
| RRC ID | 75876 |
|---|---|
| 著者 | Goode C, Voeun M, Ncube D, Eisen J, Washbourne P, Tallafuss A. |
| タイトル | Late onset of Synaptotagmin 2a expression at synapses relevant to social behavior. |
| ジャーナル | J Comp Neurol |
| Abstract |
As they form, synapses go through various stages of maturation and refinement. These steps are linked to significant changes in synaptic function, potentially resulting in emergence and maturation of behavioral outputs. Synaptotagmins are calcium-sensing proteins of the synaptic vesicle exocytosis machinery, and changes in Synaptotagmin proteins at synapses have significant effects on vesicle release and synaptic function. Here, we examined the distribution of the synaptic vesicle protein Synaptotagmin 2a (Syt2a) during development of the zebrafish nervous system. Syt2a is widely distributed throughout the midbrain and hindbrain early during larval development but very weakly expressed in the forebrain. Later in development, Syt2a expression levels in the forebrain increase, particularly in regions associated with social behavior, and most intriguingly, around the time social behavior becomes apparent. We provide evidence that Syt2a localizes to synapses onto neurons implicated in social behavior in the ventral forebrain and show that Syt2a is colocalized with tyrosine hydroxylase, a biosynthetic enzyme in the dopamine pathway. Our results suggest a developmentally important role for Syt2a in maturing synapses in the forebrain, coinciding with the emergence of social behavior. |
| 巻・号 | 529(9) |
| ページ | 2176-2188 |
| 公開日 | 2021-6-1 |
| DOI | 10.1002/cne.25084 |
| PMID | 33491202 |
| PMC | PMC8202783 |
| MeSH | Animals Animals, Genetically Modified Gene Expression Prosencephalon / embryology Prosencephalon / metabolism* Social Behavior* Synapses / genetics Synapses / metabolism* Synaptotagmin II / biosynthesis* Synaptotagmin II / genetics Zebrafish |
| IF | 2.801 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ゼブラフィッシュ | UAS:GFP |