論文 - 詳細
| RRC ID | 75909 |
|---|---|
| 著者 | Aktypi F, Papaevgeniou N, Voutetakis K, Chatziioannou A, Grune T, Chondrogianni N. |
| タイトル | Network analysis in aged C. elegans reveals candidate regulatory genes of ageing. |
| ジャーナル | Biogerontology |
| Abstract |
Ageing is a biological process guided by genetic and environmental factors that ultimately lead to adverse outcomes for organismal lifespan and healthspan. Determination of molecular pathways that are affected with age and increase disease susceptibility is crucial. The gene expression profile of the ideal ageing model, namely the nematode Caenorhabditis elegans mapped with the microarray technology initially led to the identification of age-dependent gene expression alterations that characterize the nematode's ageing process. The list of differentially expressed genes was then utilized to construct a network of molecular interactions with their first neighbors/interactors using the interactions listed in the WormBase database. The subsequent network analysis resulted in the unbiased selection of 110 candidate genes, among which well-known ageing regulators appeared. More importantly, our approach revealed candidates that have never been linked to ageing before, thus suggesting promising potential targets/ageing regulators. |
| 巻・号 | 22(3) |
| ページ | 345-367 |
| 公開日 | 2021-6-1 |
| DOI | 10.1007/s10522-021-09920-3 |
| PII | 10.1007/s10522-021-09920-3 |
| PMID | 33871732 |
| MeSH | Aging / genetics Animals Caenorhabditis elegans* / genetics Caenorhabditis elegans Proteins* / genetics Genes, Regulator Longevity / genetics |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 11 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
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