論文 - 詳細
| RRC ID | 76005 |
|---|---|
| 著者 | Ma T, Zhao L, Zhang J, Tang R, Wang X, Liu N, Zhang Q, Wang F, Li M, Shan Q, Yang Y, Yin Q, Yang L, Gan Q, Yang C. |
| タイトル | A pair of transporters controls mitochondrial Zn2+ levels to maintain mitochondrial homeostasis. |
| ジャーナル | Protein Cell |
| Abstract |
Zn2+ is required for the activity of many mitochondrial proteins, which regulate mitochondrial dynamics, apoptosis and mitophagy. However, it is not understood how the proper mitochondrial Zn2+ level is achieved to maintain mitochondrial homeostasis. Using Caenorhabditis elegans, we reveal here that a pair of mitochondrion-localized transporters controls the mitochondrial level of Zn2+. We demonstrate that SLC-30A9/ZnT9 is a mitochondrial Zn2+ exporter. Loss of SLC-30A9 leads to mitochondrial Zn2+ accumulation, which damages mitochondria, impairs animal development and shortens the life span. We further identify SLC-25A25/SCaMC-2 as an important regulator of mitochondrial Zn2+ import. Loss of SLC-25A25 suppresses the abnormal mitochondrial Zn2+ accumulation and defective mitochondrial structure and functions caused by loss of SLC-30A9. Moreover, we reveal that the endoplasmic reticulum contains the Zn2+ pool from which mitochondrial Zn2+ is imported. These findings establish the molecular basis for controlling the correct mitochondrial Zn2+ levels for normal mitochondrial structure and functions. |
| 巻・号 | 13(3) |
| ページ | 180-202 |
| 公開日 | 2022-3-1 |
| DOI | 10.1007/s13238-021-00881-4 |
| PII | 10.1007/s13238-021-00881-4 |
| PMID | 34687432 |
| PMC | PMC8901913 |
| MeSH | Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism Cation Transport Proteins* / genetics Homeostasis Mitochondria* / metabolism Zinc / metabolism |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 7 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1108 |