論文 - 詳細
| RRC ID | 76024 |
|---|---|
| 著者 | Otarigho B, Aballay A. |
| タイトル | Immunity-longevity tradeoff neurally controlled by GABAergic transcription factor PITX1/UNC-30. |
| ジャーナル | Cell Rep |
| Abstract |
A body of evidence indicates that metazoan immune and aging pathways are largely interconnected, but the mechanisms involved in their homeostatic control remain unclear. In this study, we find that the PITX (paired-like homeodomain) transcription factor UNC-30 controls the tradeoff between immunity and longevity from the nervous system in Caenorhabditis elegans. PITX/UNC-30 functional loss enhances immunity in a GATA/ELT-2- and p38 MAPK/PMK-1-dependent manner and reduced longevity by activating MXD/MDL-1 and the C2H2-type zinc finger transcription factor PQM-1. The immune inhibitory and longevity stimulatory functions of PITX/UNC-30 require the sensory neuron ASG and a signaling pathway controlled by NPR-1, which is a G protein-coupled receptor related to mammalian neuropeptide Y receptors. Our findings uncover a suppressive role of GABAergic signaling in the neural control of a biological tradeoff where energy is allocated toward immunity at the expense of longevity. |
| 巻・号 | 35(8) |
| ページ | 109187 |
| 公開日 | 2021-5-25 |
| DOI | 10.1016/j.celrep.2021.109187 |
| PII | S2211-1247(21)00533-7 |
| PMID | 34038721 |
| PMC | PMC8227953 |
| MeSH | Animals Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / metabolism* Homeodomain Proteins / metabolism* Immunity, Innate / immunology* Longevity* Nuclear Proteins / metabolism* Pseudomonas aeruginosa / metabolism* Transcription Factors / metabolism |
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 8 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm311 |