RRC ID |
76095
|
Author |
Xie K, Liu Y, Li X, Zhang H, Zhang S, Mak HY, Liu P.
|
Title |
Dietary S. maltophilia induces supersized lipid droplets by enhancing lipogenesis and ER-LD contacts in C. elegans.
|
Journal |
Gut Microbes
|
Abstract |
Dietary and symbiotic bacteria can exert powerful influence on metazoan lipid metabolism. Recent studies have emerged that microbiota have a role in animal obesity and related health disorders, but the mechanisms by which bacteria influence lipid storage in their host are unknown. To reduce the complexity of the relationship between gut microbiota and the host, Caenorhabditis elegans (C. elegans) has been chosen as a model organism to study interspecies interaction. Here, we demonstrate that feeding C. elegans with an opportunistic pathogenic bacterium Stenotrophomonas maltophilia (S. maltophilia) retards growth and promotes excessive neutral lipid storage. Gene expression analysis reveals that dietary S. maltophilia induces a lipogenic transcriptional response that includes the SREBP ortholog SBP-1, and fatty acid desaturases FAT-6 and FAT-7. Live imaging and ultrastructural analysis suggest that excess neutral lipid is stored in greatly expanded lipid droplets (LDs), as a result of enhanced endoplasmic reticulum (ER)-LD interaction. We also report that loss of function mutations in dpy-9 in C. elegans confers resistance to S. maltophilia. Dietary S. maltophilia induces supersized LDs by enhancing lipogenesis and ER-LD contacts in C. elegans. This work delineates a new model for understanding microbial regulation of metazoan physiology.
|
Volume |
14(1)
|
Pages |
2013762
|
Published |
2022-1-1
|
DOI |
10.1080/19490976.2021.2013762
|
PMID |
35112996
|
PMC |
PMC8816401
|
MeSH |
Animals
Caenorhabditis elegans / genetics
Caenorhabditis elegans / growth & development
Caenorhabditis elegans / metabolism*
Caenorhabditis elegans / microbiology*
Caenorhabditis elegans Proteins / genetics
Caenorhabditis elegans Proteins / metabolism
Endoplasmic Reticulum / genetics
Endoplasmic Reticulum / metabolism
Female
Gastrointestinal Microbiome
Lipid Droplets / metabolism*
Lipogenesis*
Male
Stearoyl-CoA Desaturase / genetics
Stearoyl-CoA Desaturase / metabolism
Stenotrophomonas maltophilia / metabolism*
Transcription Factors / genetics
Transcription Factors / metabolism
|
Resource |
C.elegans |
tm331
tm4221 |