論文 - 詳細
| RRC ID | 76127 |
|---|---|
| 著者 | Brenner JL, Jyo EM, Mohammad A, Fox P, Jones V, Mardis E, Schedl T, Maine EM. |
| タイトル | TRIM-NHL protein, NHL-2, modulates cell fate choices in the C. elegans germ line. |
| ジャーナル | Dev Biol |
| Abstract |
Many tissues contain multipotent stem cells that are critical for maintaining tissue function. In Caenorhabditis elegans, germline stem cells allow gamete production to continue in adulthood. In the gonad, GLP-1/Notch signaling from the distal tip cell niche to neighboring germ cells activates a complex regulatory network to maintain a stem cell population. GLP-1/Notch signaling positively regulates production of LST-1 and SYGL-1 proteins that, in turn, interact with a set of PUF/FBF proteins to positively regulate the stem cell fate. We previously described sog (suppressor of glp-1 loss of function) and teg (tumorous enhancer of glp-1 gain of function) genes that limit the stem cell fate and/or promote the meiotic fate. Here, we show that sog-10 is allelic to nhl-2. NHL-2 is a member of the conserved TRIM-NHL protein family whose members can bind RNA and ubiquitinate protein substrates. We show that NHL-2 acts, at least in part, by inhibiting the expression of PUF-3 and PUF-11 translational repressor proteins that promote the stem cell fate. Two other negative regulators of stem cell fate, CGH-1 (conserved germline helicase) and ALG-5 (Argonaute protein), may work with NHL-2 to modulate the stem cell population. In addition, NHL-2 activity promotes the male germ cell fate in XX animals. |
| 巻・号 | 491 |
| ページ | 43-55 |
| 公開日 | 2022-11-1 |
| DOI | 10.1016/j.ydbio.2022.08.010 |
| PII | S0012-1606(22)00162-2 |
| PMID | 36063869 |
| PMC | PMC9922029 |
| MeSH | Animals Argonaute Proteins / metabolism Caenorhabditis elegans* / genetics Caenorhabditis elegans* / metabolism Caenorhabditis elegans Proteins* / genetics Caenorhabditis elegans Proteins* / metabolism Carrier Proteins / metabolism Germ Cells / metabolism Glucagon-Like Peptide 1 / genetics Glucagon-Like Peptide 1 / metabolism Male RNA / metabolism RNA Nucleotidyltransferases / metabolism RNA-Binding Proteins / genetics RNA-Binding Proteins / metabolism Receptors, Notch / metabolism Repressor Proteins / metabolism Transcription Factors / metabolism Tripartite Motif Proteins / metabolism |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1163 |