Reference - Detail
| RRC ID | 76129 |
|---|---|
| Author | Bujarrabal-Dueso A, Sendtner G, Meyer DH, Chatzinikolaou G, Stratigi K, Garinis GA, Schumacher B. |
| Title | The DREAM complex functions as conserved master regulator of somatic DNA-repair capacities. |
| Journal | Nat Struct Mol Biol |
| Abstract |
The DNA-repair capacity in somatic cells is limited compared with that in germ cells. It has remained unknown whether not only lesion-type-specific, but overall repair capacities could be improved. Here we show that the DREAM repressor complex curbs the DNA-repair capacities in somatic tissues of Caenorhabditis elegans. Mutations in the DREAM complex induce germline-like expression patterns of multiple mechanisms of DNA repair in the soma. Consequently, DREAM mutants confer resistance to a wide range of DNA-damage types during development and aging. Similarly, inhibition of the DREAM complex in human cells boosts DNA-repair gene expression and resistance to distinct DNA-damage types. DREAM inhibition leads to decreased DNA damage and prevents photoreceptor loss in progeroid Ercc1-/- mice. We show that the DREAM complex transcriptionally represses essentially all DNA-repair systems and thus operates as a highly conserved master regulator of the somatic limitation of DNA-repair capacities. |
| Volume | 30(4) |
| Pages | 475-488 |
| Published | 2023-4-1 |
| DOI | 10.1038/s41594-023-00942-8 |
| PII | 10.1038/s41594-023-00942-8 |
| PMID | 36959262 |
| PMC | PMC10113156 |
| MeSH | Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins* / genetics Caenorhabditis elegans Proteins* / metabolism DNA / metabolism DNA Damage DNA Repair Germ Cells / metabolism Humans Mice |
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 571 |
| Altmetric score changes over past 6months | 9.5 |
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| C.elegans | tm3886 tm1489 tm4539 tm1524 tm1145 |