| RRC ID |
76136
|
| 著者 |
Chai CM, Park H, Sternberg PW.
|
| タイトル |
Brain-wide bidirectional neuropeptide modulation of individual neuron classes regulates a developmental decision.
|
| ジャーナル |
Curr Biol
|
| Abstract |
Secreted neuromodulators, like biogenic amines and neuropeptides, can reconfigure circuit functions both locally and at a distance and establish global brain states that alter circuit outputs over prolonged timescales.1-3 Despite their diversity and ubiquitous presence, many studies on neuromodulation tend to focus on dissecting the function and site of action of individual neuropeptides. Here, we take a different approach by conducting a systems-level investigation of neuropeptide receptor signaling function and cell-type-specific distribution in the context of the Caenorhabditis elegans diapause entry developmental decision. C. elegans diapause entry is controlled by sensory perception of external factors and is regulated by neuropeptide signaling.4-8 We performed a comprehensive functional screen of neuropeptide receptor mutants for pheromone-induced diapause entry phenotypes and integrated these results with published C. elegans single-cell RNA-seq data to reveal that almost all neuron classes expressed at least one receptor with a role in diapause entry.9 Our receptor expression analysis also identified four highly modulated neural hubs with no previously reported roles in diapause entry that are distributed throughout the animal's body, possibly as a means of synchronizing the whole-organism transition into the appropriate larval morph. Furthermore, most neuron classes expressed unique neuropeptide receptor repertoires that have opposing effects on the diapause entry decision. We propose that brain-wide antagonistic neuropeptide modulation of individual neuron classes by distinct neuropeptide receptor subsets could serve as a strategy against overmodulation and that this motif might generalize to other decision-making paradigms in other organisms.
|
| 巻・号 |
32(15)
|
| ページ |
3365-3373.e6
|
| 公開日 |
2022-8-8
|
| DOI |
10.1016/j.cub.2022.05.048
|
| PII |
S0960-9822(22)00851-X
|
| PMID |
35679871
|
| PMC |
PMC10588560
|
| MeSH |
Animals
Brain / metabolism
Caenorhabditis elegans / physiology
Caenorhabditis elegans Proteins* / metabolism
Neurons / metabolism
Neuropeptides* / metabolism
Receptors, Neuropeptide / metabolism
|
| リソース情報 |
| 線虫 |
tm6135
tm7561
tm1583
tm1782
tm1498
tm1504
tm3210
tm6617
tm1665
tm7831
tm4152
tm4218
tm4160
tm4944
tm4155
tm2243
tm5157
tm4782
tm1848
tm3658
tm3668
tm3625
tm3082 |
