論文 - 詳細
| RRC ID | 76136 |
|---|---|
| 著者 | Chai CM, Park H, Sternberg PW. |
| タイトル | Brain-wide bidirectional neuropeptide modulation of individual neuron classes regulates a developmental decision. |
| ジャーナル | Curr Biol |
| Abstract |
Secreted neuromodulators, like biogenic amines and neuropeptides, can reconfigure circuit functions both locally and at a distance and establish global brain states that alter circuit outputs over prolonged timescales.1-3 Despite their diversity and ubiquitous presence, many studies on neuromodulation tend to focus on dissecting the function and site of action of individual neuropeptides. Here, we take a different approach by conducting a systems-level investigation of neuropeptide receptor signaling function and cell-type-specific distribution in the context of the Caenorhabditis elegans diapause entry developmental decision. C. elegans diapause entry is controlled by sensory perception of external factors and is regulated by neuropeptide signaling.4-8 We performed a comprehensive functional screen of neuropeptide receptor mutants for pheromone-induced diapause entry phenotypes and integrated these results with published C. elegans single-cell RNA-seq data to reveal that almost all neuron classes expressed at least one receptor with a role in diapause entry.9 Our receptor expression analysis also identified four highly modulated neural hubs with no previously reported roles in diapause entry that are distributed throughout the animal's body, possibly as a means of synchronizing the whole-organism transition into the appropriate larval morph. Furthermore, most neuron classes expressed unique neuropeptide receptor repertoires that have opposing effects on the diapause entry decision. We propose that brain-wide antagonistic neuropeptide modulation of individual neuron classes by distinct neuropeptide receptor subsets could serve as a strategy against overmodulation and that this motif might generalize to other decision-making paradigms in other organisms. |
| 巻・号 | 32(15) |
| ページ | 3365-3373.e6 |
| 公開日 | 2022-8-8 |
| DOI | 10.1016/j.cub.2022.05.048 |
| PII | S0960-9822(22)00851-X |
| PMID | 35679871 |
| PMC | PMC10588560 |
| MeSH | Animals Brain / metabolism Caenorhabditis elegans / physiology Caenorhabditis elegans Proteins* / metabolism Neurons / metabolism Neuropeptides* / metabolism Receptors, Neuropeptide / metabolism |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm6135 tm7561 tm1583 tm1782 tm1498 tm1504 tm3210 tm6617 tm1665 tm7831 tm4152 tm4218 tm4160 tm4944 tm4155 tm2243 tm5157 tm4782 tm1848 tm3658 tm3668 tm3625 tm3082 |