論文 - 詳細
| RRC ID | 76176 |
|---|---|
| 著者 | Gong T, McNally FJ. |
| タイトル | Caenorhabditis elegans spermatocytes can segregate achiasmate homologous chromosomes apart at higher than random frequency during meiosis I. |
| ジャーナル | Genetics |
| Abstract |
Chromosome segregation errors during meiosis are the leading cause of aneuploidy. Faithful chromosome segregation during meiosis in most eukaryotes requires a crossover which provides a physical attachment holding homologs together in a "bivalent." Crossovers are critical for homologs to be properly aligned and partitioned in the first meiotic division. Without a crossover, individual homologs (univalents) might segregate randomly, resulting in aneuploid progeny. However, Caenorhabditis elegans zim-2 mutants, which have crossover defects on chromosome V, have fewer dead embryos than that expected from random segregation. This deviation from random segregation is more pronounced in zim-2 males than that in females. We found three phenomena that can explain this apparent discrepancy. First, we detected crossovers on chromosome V in both zim-2(tm574) oocytes and spermatocytes, suggesting a redundant mechanism to make up for the ZIM-2 loss. Second, after accounting for the background crossover frequency, spermatocytes produced significantly more euploid gametes than what would be expected from random segregation. Lastly, trisomy of chromosome V is viable and fertile. Together, these three phenomena allow zim-2(tm574) mutants with reduced crossovers on chromosome V to have more viable progeny. Furthermore, live imaging of meiosis in spo-11(me44) oocytes and spermatocytes, which exhibit crossover failure on all 6 chromosomes, showed 12 univalents segregating apart in roughly equal masses in a homology-independent manner, supporting the existence of a mechanism that segregates any 2 chromosomes apart. |
| 巻・号 | 223(4) |
| 公開日 | 2023-4-6 |
| DOI | 10.1093/genetics/iyad021 |
| PII | 7040747 |
| PMID | 36792551 |
| PMC | PMC10319977 |
| MeSH | Aneuploidy Animals Caenorhabditis elegans* / genetics Caenorhabditis elegans Proteins* / genetics Chromosome Segregation / genetics Chromosomes / genetics Female Male Meiosis / genetics Spermatocytes |
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