論文 - 詳細
| RRC ID | 76183 |
|---|---|
| 著者 | Handley A, Wu Q, Sherry T, Cornell R, Pocock R. |
| タイトル | Diet-responsive transcriptional regulation of insulin in a single neuron controls systemic metabolism. |
| ジャーナル | PLoS Biol |
| Abstract |
Metabolic homeostasis is coordinated through a robust network of signaling pathways acting across all tissues. A key part of this network is insulin-like signaling, which is fundamental for surviving glucose stress. Here, we show that Caenorhabditis elegans fed excess dietary glucose reduce insulin-1 (INS-1) expression specifically in the BAG glutamatergic sensory neurons. We demonstrate that INS-1 expression in the BAG neurons is directly controlled by the transcription factor ETS-5, which is also down-regulated by glucose. We further find that INS-1 acts exclusively from the BAG neurons, and not other INS-1-expressing neurons, to systemically inhibit fat storage via the insulin-like receptor DAF-2. Together, these findings reveal an intertissue regulatory pathway where regulation of insulin expression in a specific neuron controls systemic metabolism in response to excess dietary glucose. |
| 巻・号 | 20(5) |
| ページ | e3001655 |
| 公開日 | 2022-5-1 |
| DOI | 10.1371/journal.pbio.3001655 |
| PII | PBIOLOGY-D-21-02978 |
| PMID | 35594303 |
| PMC | PMC9162364 |
| MeSH | Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins* / genetics Caenorhabditis elegans Proteins* / metabolism Diet Forkhead Transcription Factors / metabolism Glucose / metabolism Insulin* / metabolism Neurons / metabolism Receptor, Insulin / genetics Receptor, Insulin / metabolism |
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オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 26 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1734 tm1888 |