Reference - Detail
| RRC ID | 76204 |
|---|---|
| Author | Kageyama N, Nose M, Ono M, Matsunaga Y, Iwasaki T, Kawano T. |
| Title | The FMRFamide-like peptide FLP-2 is involved in the modulation of larval development and adult lifespan by regulating the secretion of the insulin-like peptide INS-35 in Caenorhabditis elegans. |
| Journal | Biosci Biotechnol Biochem |
| Abstract |
In the animal kingdom, neuropeptides regulate diverse physiological functions. In invertebrates, FMRFamide and its related peptides, a family of neuropeptides, play an important role as neurotransmitters. The FMRFamide-like peptides (FLPs) are one of the most diverse neuropeptide families and are conserved in nematodes. Our screen for flp genes of the free-living soil nematode Caenorhabditis elegans revealed that the flp-2 gene is involved in the larval development. The gene is also conserved in plant-parasitic root-knot nematodes. Our molecular genetic analyses of the C. elegans flp-2 gene demonstrated as follows: (1) the production and secretion of FLP-2, produced in the head neurons, are controlled by environmental factors (growth density and food); (2) the FLP-2 is involved in not only larval development but also adult lifespan by regulating the secretion of one of the insulin-like peptides INS-35, produced in the intestine. These findings provide new insight into the development of new nematicides. |
| Volume | 86(9) |
| Pages | 1231-1239 |
| Published | 2022-8-24 |
| DOI | 10.1093/bbb/zbac108 |
| PII | 6628775 |
| PMID | 35786701 |
| MeSH | Animals Caenorhabditis elegans* / genetics FMRFamide / chemistry FMRFamide / genetics Insulin Longevity / genetics Neuropeptides* / genetics Peptides / genetics |
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| Total number of mentions | 3 |
| Altmetric score changes over past 6months | 0.0 |
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| C.elegans | |