| RRC ID |
76204
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| 著者 |
Kageyama N, Nose M, Ono M, Matsunaga Y, Iwasaki T, Kawano T.
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| タイトル |
The FMRFamide-like peptide FLP-2 is involved in the modulation of larval development and adult lifespan by regulating the secretion of the insulin-like peptide INS-35 in Caenorhabditis elegans.
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| ジャーナル |
Biosci Biotechnol Biochem
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| Abstract |
In the animal kingdom, neuropeptides regulate diverse physiological functions. In invertebrates, FMRFamide and its related peptides, a family of neuropeptides, play an important role as neurotransmitters. The FMRFamide-like peptides (FLPs) are one of the most diverse neuropeptide families and are conserved in nematodes. Our screen for flp genes of the free-living soil nematode Caenorhabditis elegans revealed that the flp-2 gene is involved in the larval development. The gene is also conserved in plant-parasitic root-knot nematodes. Our molecular genetic analyses of the C. elegans flp-2 gene demonstrated as follows: (1) the production and secretion of FLP-2, produced in the head neurons, are controlled by environmental factors (growth density and food); (2) the FLP-2 is involved in not only larval development but also adult lifespan by regulating the secretion of one of the insulin-like peptides INS-35, produced in the intestine. These findings provide new insight into the development of new nematicides.
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| 巻・号 |
86(9)
|
| ページ |
1231-1239
|
| 公開日 |
2022-8-24
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| DOI |
10.1093/bbb/zbac108
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| PII |
6628775
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| PMID |
35786701
|
| MeSH |
Animals
Caenorhabditis elegans* / genetics
FMRFamide / chemistry
FMRFamide / genetics
Insulin
Longevity / genetics
Neuropeptides* / genetics
Peptides / genetics
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| リソース情報 |
| 線虫 |
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