| RRC ID |
76211
|
| Author |
Labarre A, Guitard E, Tossing G, Forest A, Bareke E, Labrecque M, Tétreault M, Ruiz M, Alex Parker J.
|
| Title |
Fatty acids derived from the probiotic Lacticaseibacillus rhamnosus HA-114 suppress age-dependent neurodegeneration.
|
| Journal |
Commun Biol
|
| Abstract |
The human microbiota is believed to influence health. Microbiome dysbiosis may be linked to neurological conditions like Alzheimer's disease, amyotrophic lateral sclerosis, and Huntington's disease. We report the ability of a probiotic bacterial strain in halting neurodegeneration phenotypes. We show that Lacticaseibacillus rhamnosus HA-114 is neuroprotective in C. elegans models of amyotrophic lateral sclerosis and Huntington's disease. Our results show that neuroprotection from L. rhamnosus HA-114 is unique from other L. rhamnosus strains and resides in its fatty acid content. Neuroprotection by L. rhamnosus HA-114 requires acdh-1/ACADSB, kat-1/ACAT1 and elo-6/ELOVL3/6, which are associated with fatty acid metabolism and mitochondrial β-oxidation. Our data suggest that disrupted lipid metabolism contributes to neurodegeneration and that dietary intervention with L. rhamnosus HA-114 restores lipid homeostasis and energy balance through mitochondrial β-oxidation. Our findings encourage the exploration of L. rhamnosus HA-114 derived interventions to modify the progression of neurodegenerative diseases.
|
| Volume |
5(1)
|
| Pages |
1340
|
| Published |
2022-12-7
|
| DOI |
10.1038/s42003-022-04295-8
|
| PII |
10.1038/s42003-022-04295-8
|
| PMID |
36477191
|
| PMC |
PMC9729297
|
| MeSH |
Amyotrophic Lateral Sclerosis*
Animals
Caenorhabditis elegans
Fatty Acids
Humans
Huntington Disease*
Lacticaseibacillus
Lacticaseibacillus rhamnosus*
|
| Resource |
| C.elegans |
tm3278
tm1037 |
