論文 - 詳細
| RRC ID | 76230 |
|---|---|
| 著者 | Ma A, Feng Q, Li P, Yuan L, Xiao H. |
| タイトル | SCAV-3 affects apoptotic cell degradation in Caenorhabditis elegans. |
| ジャーナル | FEBS Open Bio |
| Abstract |
As the final step in apoptosis, apoptotic cells (ACs) are swiftly removed by specialized phagocytes, such as macrophages, or nonprofessional phagocytes, such as epidermal cells. Genetic studies of model organisms such as Caenorhabditis elegans have helped to elucidate the mechanisms of AC clearance and the underlying causes of disorders related to the dysregulation of these pathways. C. elegans possesses six class B scavenger receptor homologs, but whether they affect apoptosis is unknown. Here, we show that only the loss of function of scav-3, the C. elegans homolog of human lysosomal integral membrane protein-2, resulted in a considerable accumulation of cell corpses, which was caused by a failure in degradation rather than engulfment. SCAV-3 was found to be widely distributed and localized in lysosomes to maintain the integrity of the lysosomal membrane. Further study revealed that loss of scav-3 had no effect on phagosome maturation or the recruitment of lysosomes to phagosomes carrying cell corpses. Moreover, we discovered that the hydrolytic enzymes contained in the lysosomes were reduced in phagosomes in scav-3 mutants. Thus, hydrolases may leak from the damaged lysosome during phagolysosome formation due to the loss of scav-3 function, which reduces lysosome digestion activity and thus directly contributes to the elimination of ACs. |
| 巻・号 | 13(5) |
| ページ | 867-880 |
| 公開日 | 2023-5-1 |
| DOI | 10.1002/2211-5463.13599 |
| PMID | 36947094 |
| PMC | PMC10153301 |
| MeSH | Animals Apoptosis Caenorhabditis elegans* / metabolism Caenorhabditis elegans Proteins* / genetics Caenorhabditis elegans Proteins* / metabolism Humans Lysosomes / metabolism Phagocytosis |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1125 |