論文 - 詳細
| RRC ID | 76238 |
|---|---|
| 著者 | Matty MA, Lau HE, Haley JA, Singh A, Chakraborty A, Kono K, Reddy KC, Hansen M, Chalasani SH. |
| タイトル | Intestine-to-neuronal signaling alters risk-taking behaviors in food-deprived Caenorhabditis elegans. |
| ジャーナル | PLoS Genet |
| Abstract |
Animals integrate changes in external and internal environments to generate behavior. While neural circuits detecting external cues have been mapped, less is known about how internal states like hunger are integrated into behavioral outputs. Here, we use the nematode C. elegans to examine how changes in internal nutritional status affect chemosensory behaviors. We show that acute food deprivation leads to a reversible decline in repellent, but not attractant, sensitivity. This behavioral change requires two conserved transcription factors MML-1 (MondoA) and HLH-30 (TFEB), both of which translocate from the intestinal nuclei to the cytoplasm during food deprivation. Next, we identify the insulin-like peptide INS-31 as a candidate ligand relaying food-status signals from the intestine to other tissues. Further, we show that neurons likely use the DAF-2 insulin receptor and AGE-1/PI-3 Kinase, but not DAF-16/FOXO to integrate these intestine-released peptides. Altogether, our study shows how internal food status signals are integrated by transcription factors and intestine-neuron signaling to generate flexible behaviors via the gut-brain axis. |
| 巻・号 | 18(5) |
| ページ | e1010178 |
| 公開日 | 2022-5-1 |
| DOI | 10.1371/journal.pgen.1010178 |
| PII | PGENETICS-D-21-01159 |
| PMID | 35511794 |
| PMC | PMC9070953 |
| MeSH | Animals Basic Helix-Loop-Helix Transcription Factors Caenorhabditis elegans* / genetics Caenorhabditis elegans Proteins* / genetics Forkhead Transcription Factors Insulin Intestines Risk-Taking Transcription Factors / genetics |
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 66 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1516 tm1978 tm3603 tm339 tm3620 tm2416 tm3498 tm790 tm1875 tm3543 tm2001 tm4144 tm6061 tm1053 |