RRC ID 76247
Author Motomura H, Ioroi M, Murakami K, Kuhara A, Ohta A.
Title Head-tail-head neural wiring underlies gut fat storage in Caenorhabditis elegans temperature acclimation.
Journal Proc Natl Acad Sci U S A
Abstract Animals maintain the ability to survive and reproduce by acclimating to environmental temperatures. We showed here that Caenorhabditis elegans exhibited temperature acclimation plasticity, which was regulated by a head-tail-head neural circuitry coupled with gut fat storage. After experiencing cold, C. elegans individuals memorized the experience and were prepared against subsequent cold stimuli. The cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB) regulated temperature acclimation in the ASJ thermosensory neurons and RMG head interneurons, where it modulated ASJ thermosensitivity in response to past cultivation temperature. The PVQ tail interneurons mediated the communication between ASJ and RMG via glutamatergic signaling. Temperature acclimation occurred via gut fat storage regulation by the triglyceride lipase ATGL-1, which was activated by a neuropeptide, FLP-7, downstream of CREB. Thus, a head-tail-head neural circuit coordinated with gut fat influenced experience-dependent temperature acclimation.
Volume 119(32)
Pages e2203121119
Published 2022-8-9
DOI 10.1073/pnas.2203121119
PMID 35914124
PMC PMC9371718
MeSH Acclimatization* / physiology Adipose Tissue* / metabolism Animals Caenorhabditis elegans* / anatomy & histology Caenorhabditis elegans* / physiology Caenorhabditis elegans Proteins / metabolism Cold Temperature* Cyclic AMP Response Element-Binding Protein / metabolism Digestive System* / metabolism Glutamic Acid / metabolism Head* / innervation Interneurons / metabolism Lipase / metabolism Neural Pathways* Neuropeptides / metabolism Tail* / innervation Thermosensing
Resource
C.elegans tm3239 tm3506 tm1811 tm355 tm8953