論文 - 詳細
| RRC ID | 76278 |
|---|---|
| 著者 | Ren J, Sang Y, Aballay A. |
| タイトル | Cholinergic receptor-Wnt pathway controls immune activation by sensing intestinal dysfunction. |
| ジャーナル | Cell Rep |
| Abstract |
Alterations in the intestinal physiology caused by pathogen colonization result in immune activation. To provide insights into the mechanisms underlying the control of immune activation by changes in intestinal homeostasis, we conducted a forward genetic screen for suppressors of immune activation by intestinal distension in Caenorhabditis elegans. Our results indicate that C. elegans ACC-4, a member of a family of acetylcholine receptors, is required in immune activation by defects in the defecation motor program or by pathogen infection. ACC-4 acts postsynaptically in non-cholinergic RIM neurons to regulate several immune genes and a Wnt-mediated host immune response. These findings uncover a gut-brain-microbial axis that uses neural cholinergic signaling and the Wnt pathway to control immune activation in response to alterations in intestinal homeostasis. |
| 巻・号 | 41(5) |
| ページ | 111575 |
| 公開日 | 2022-11-1 |
| DOI | 10.1016/j.celrep.2022.111575 |
| PII | S2211-1247(22)01436-X |
| PMID | 36323254 |
| PMC | PMC9699718 |
| MeSH | Animals Caenorhabditis elegans* / metabolism Caenorhabditis elegans Proteins* / metabolism Cholinergic Agents / metabolism Receptors, Cholinergic / metabolism Wnt Signaling Pathway |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 13 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.2 |
| リソース情報 | |
| 線虫 | tm2706 |