Reference - Detail
| RRC ID | 76280 |
|---|---|
| Author | Riva C, Hajduskova M, Gally C, Suman SK, Ahier A, Jarriault S. |
| Title | A natural transdifferentiation event involving mitosis is empowered by integrating signaling inputs with conserved plasticity factors. |
| Journal | Cell Rep |
| Abstract |
Transdifferentiation, or direct cell reprogramming, is the conversion of one fully differentiated cell type into another. Whether core mechanisms are shared between natural transdifferentiation events when occurring with or without cell division is unclear. We have previously characterized the Y-to-PDA natural transdifferentiation in Caenorhabditis elegans, which occurs without cell division and requires orthologs of vertebrate reprogramming factors. Here, we identify a rectal-to-GABAergic transdifferentiation and show that cell division is required but not sufficient for conversion. We find shared mechanisms, including erasure of the initial identity, which requires the conserved reprogramming factors SEM-4/SALL, SOX-2, CEH-6/OCT, and EGL-5/HOX. We also find three additional and parallel roles of the Wnt signaling pathway: selection of a specific daughter, removal of the initial identity, and imposition of the precise final subtype identity. Our results support a model in which levels and antagonistic activities of SOX-2 and Wnt signaling provide a timer for the acquisition of final identity. |
| Volume | 40(12) |
| Pages | 111365 |
| Published | 2022-9-20 |
| DOI | 10.1016/j.celrep.2022.111365 |
| PII | S2211-1247(22)01197-4 |
| PMID | 36130499 |
| PMC | PMC9513805 |
| MeSH | Animals Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins* / genetics Caenorhabditis elegans Proteins* / metabolism Cell Transdifferentiation Mitosis Wnt Signaling Pathway |
| Altmetric score |
オルトメトリクス指標項目
|
| The most frequently cited source | X(Twitter) |
| Total number of mentions | 13 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm1422 tm2639 |