論文 - 詳細
| RRC ID | 76315 |
|---|---|
| 著者 | Une R, Kageyama N, Ono M, Matsunaga Y, Iwasaki T, Kawano T. |
| タイトル | The FMRFamide-like peptide FLP-1 modulates larval development by regulating the production and secretion of the insulin-like peptide DAF-28 in Caenorhabditis elegans. |
| ジャーナル | Biosci Biotechnol Biochem |
| Abstract |
The FMRFamide-like peptides (FLPs) are conserved in both free-living and parasitic nematodes. This molecular genetic study verified the relevance of the flp-1 gene, which is conserved in many nematode species, to the larval development of the free-living soil nematode Caenorhabditis elegans. Using C. elegans as a model, we found that: (1) FLP-1 suppressed larval development, resulting in diapause; (2) the secretion of FLP-1, which is produced in AVK head neurons, was suppressed by the presence of food (Escherichia coli) as an environmental factor to continue larval development; (3) the FLP-1 reduced the production and secretion of DAF-28, which is produced in ASI head neurons and is the predominant insulin-like peptide (INS) present. FLP-1 is conserved in many species of plant-parasitic root-knot nematodes that cause severe damage to crops. Therefore, our findings may provide insight into the development of new nematicides that can disturb their infection and development. |
| 巻・号 | 87(2) |
| ページ | 171-178 |
| 公開日 | 2023-1-24 |
| DOI | 10.1093/bbb/zbac187 |
| PII | 6888007 |
| PMID | 36507740 |
| MeSH | Animals Caenorhabditis elegans / genetics Caenorhabditis elegans Proteins* / genetics FMRFamide / chemistry FMRFamide / genetics Insulin Nematoda* / genetics Neuropeptides* Peptides |
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