論文 - 詳細
| RRC ID | 76335 |
|---|---|
| 著者 | Yu Z, Kim HJ, Dernburg AF. |
| タイトル | ATM signaling modulates cohesin behavior in meiotic prophase and proliferating cells. |
| ジャーナル | Nat Struct Mol Biol |
| Abstract |
Cohesins are ancient and ubiquitous regulators of chromosome architecture and function, but their diverse roles and regulation remain poorly understood. During meiosis, chromosomes are reorganized as linear arrays of chromatin loops around a cohesin axis. This unique organization underlies homolog pairing, synapsis, double-stranded break induction, and recombination. We report that axis assembly in Caenorhabditis elegans is promoted by DNA-damage response (DDR) kinases that are activated at meiotic entry, even in the absence of DNA breaks. Downregulation of the cohesin-destabilizing factor WAPL-1 by ATM-1 promotes axis association of cohesins containing the meiotic kleisins COH-3 and COH-4. ECO-1 and PDS-5 also contribute to stabilizing axis-associated meiotic cohesins. Further, our data suggest that cohesin-enriched domains that promote DNA repair in mammalian cells also depend on WAPL inhibition by ATM. Thus, DDR and Wapl seem to play conserved roles in cohesin regulation in meiotic prophase and proliferating cells. |
| 巻・号 | 30(4) |
| ページ | 436-450 |
| 公開日 | 2023-4-1 |
| DOI | 10.1038/s41594-023-00929-5 |
| PII | 10.1038/s41594-023-00929-5 |
| PMID | 36879153 |
| PMC | PMC10113158 |
| MeSH | Animals Caenorhabditis elegans / genetics Cell Cycle Proteins / genetics Chromosomal Proteins, Non-Histone* / genetics Chromosome Pairing Chromosomes Cohesins Mammals / genetics Meiosis* |
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オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 17 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm853 |